116137-73-6

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 6-butyl-
• CAS NO: 116137-73-6
• Molecular Formula: C8H12N2O2
• Molecular Weight: 168.195
• Mol File: 116137-73-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 6-butyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 6-butyl-(116137-73-6)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 6-butyl-(116137-73-6)

Safety Data

• Hazardous Substances Data: 116137-73-6(Hazardous Substances Data)

Usage

General Description

2,4(1H,3H)-Pyrimidinedione, 6-butyl- is a chemical compound with the molecular formula C9H14N2O2. It is a derivative of pyrimidine and contains a butyl group attached to the sixth position of the pyrimidine ring. 2,4(1H,3H)-Pyrimidinedione, 6-butyl- has a variety of potential applications, including use as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It may also have biological activity and could be used as a building block in medicinal chemistry research. Additionally, 2,4(1H,3H)-Pyrimidinedione, 6-butyl- may have potential industrial uses and could be of interest to researchers in the fields of organic chemistry and chemical synthesis.

Upstream product

• 116137-68-9 4-Butyl-2,6-bis-methylsulfanyl-pyrimidine 
• 53939-84-7 6-butyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 114425-97-7 6-butyl-2-(methylthio)pyrimidin-4(3H)-one 
• 591-78-6 n-hexan-2-one 
• 7737-62-4 Ethyl 3-oxoheptanoate 
• 53939-84-7 6-n-butyl-2-thio-4-hydroxypyrimidine 

Downstream Products

• 821795-62-4 3-benzhydryl-1-benzyl-6-butyl-1H-pyrimidine-2,4-dione 
• 821795-54-4 3-benzhydryl-6-butyl-1H-pyrimidine-2,4-dione 

Relevant articles and documents

DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

Structure-Activity Relations. Part 12. Antibacterial Activity of a Series of 2,4-Diamino-6-substituted 5-(4-pyridylmethylamino)pyrimidines and 2,4-Diamino-5-(4-substituted benzylamino)pyrimidines.

A series of 6-substituted 2,4-diamino-5-(4-pyridylamino)pyrimidines and of 2,4-diamino-5-(4-substituted benzylamino)pyrimidines has been prepared.Their antibacterial activity towards L. casei, S. aureus and E. coli has been investigated.These activities have been successfully correlated by Hansch-type relations.Dependence on both lipophilicity and electronic (polar) factors has been found.The results are related to the structure and interactions with the receptor.