116171-95-0

Upstream product

• 116556-59-3 3-benzyloxycarbonyl-5-(3-methansulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester 
• 116527-78-7 2-(3-benzyloxypropyl)-2,3,5,6,11,11b-hexahydro-1H-indolizino<8,7-b>indol-3-on 
• 116171-90-5 3-benzyloxycarbonyl-7-methansulfonyloxymethyl-9-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester 
• 107688-25-5 3-benzyloxycarbonyl-7-benzyloxymethyl-9-acetoxy-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol 
• 107688-25-5 3-benzyloxycarbonyl-7-benzyloxymethyl-9-hydroxy-1,2,3,4,5,6,7,8,9,10-decahydroazacyclo-undecino<5,4-b>indol 
• 107688-23-3 2-benzyloxymethyl-2,3,4,5,6,7,8,13,13b-octahydro-1H-azepino<1',2':1,2>pyrido<3,4-b>indol 
• 107688-29-9 7-hydroxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester 
• 116197-10-5 (S)-4b-Chloro-9-(3-methanesulfonyloxy-propyl)-5,6,8,9,10,11-hexahydro-4bH-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 7-benzyl ester 11-methyl ester 
• 116171-97-2 3-benzyloxycarbonyl-5-(3-hydroxypropyl)-1,2,3,4,5,6,7,8-actahydroazonino<5,4-b>indol-7-carbonsauremethylester 
• 116556-55-9 5-(3-hydroxypropyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester 
• 116556-60-6 3-benzyloxycarbonyl-5-(3-p-toluolsulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester 
• 107688-24-4 3-benzyloxycarbonyl-7-benzyloxymethyl-9-hydroxy-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol 
• 116527-75-4 2-(3-benzyloxypropyl)-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino<8,7-b>indol-2-carbonsaure-ethylester 
• 116527-74-3 2-(3-benzyloxypropyl)-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino<8,7-b>indol-2-carbonsaure 

Relevant academic research and scientific papers

EINE NEUE SYNTHESE VON VINBLASTIN-DERIVATEN III. SYNTHESE UND REAKTIONEN VON 21,Nb-SECO-CLEAVAMIN-DERIVATEN ALS VORLAUFER ZU 20'-DEETHYL-20'-DEOXYVINBLASTIN UND (+/-)-16α-METHOXYCARBONYL-20-DEETHYL-15,20-DIHYDROCLEAVAMIN

In a new concept for the synthesis of 20'-deethyl-20'deoxyvinblastine, Nb-seco-cleavamine derivatives 1a,2a are possible precursors.For the synthesis of these compounds the indolizino indoles 8I,II were treated with benzyl chloroformate/aq. sodium

EINE NEUE SYNTHESE VON VINBLASTIN-DERIVATEN IV . SYNTHESE VON 20'-DEETHYL-20'-DEOXYVINBLASTIN und 20'-DEETHYL-20'-DEOXYVINCOVALIN UEBER 3,Nb-SECO-CLEAVAMIN-DERIVATIVE ALS ZWISCHENSTUFEN

Coupling of racemic 16-methoxycarbonyl-15,20-dihydro-3,Nb-seco-cleavamine derivative 34 with (-)vindoline via chloroindolenine intermediate 41 occurs with high stereoselectivity and leads after cyclization to the separable dimers 46I and 46II with natural C(14'), C(16')-configuration in good yields.Tetracyclic lactam 37 with vinblastine analogous stereochemistry is prepared and transfomed to chloroindolenine 38.Coupling of 38 with N,N-dimethyl-m-anisidine was achieved in good yield.