116172-07-7Relevant academic research and scientific papers
A NEW APPROACH TO THE SYNTHESIS OF PENTACYCLIC INDOLE DERIVATIVES RELATED TO ASPIDOSPERMA ALKALOIDS
Jackson, Anthony H.,Shannon, Patrick V. R.,Wilkins, David J.
, p. 4901 - 4904 (1987)
N-Indolylethyl-2-pyridones bearing appropriate β-dicarbonyl substituents in the 3-position have been cyclised to pentacyclic indoles via spirocyclic indolenines by catalysis with trifluoroacetic anhydride.
Electrophilic Substitution in Indoles. Part 19. Facile Syntheses of the 2a,5a-Diazacyclopentafluorene, Indoloquinolizinone and Aspidosperma Alkaloid Ring Systems from N-Acyltryptamines
Wilkins, David J.,Jackson, Anthony H.,Shannon, Patrick V. R.
, p. 299 - 308 (2007/10/02)
Reaction of tryptamine with diketene gave N--3-oxobutyramide (80percent) which with phosphoryl chloride in dichloromethane gave (9bS*,9cS*)-1,2,9b,9c-tetrahydro-5-methyl-2a,5a-diazacyclopentafluoren-3-one 13 (73percent).Hydrog
