1161817-38-4Relevant academic research and scientific papers
Synthesis of 3-aminoisoxazoles via the addition-elimination of amines on 3-bromoisoxazolines
Girardin, Melina,Alsabeh, Pamela G.,Lauzon, Sophie,Dolman, Sarah J.,Ouellet, Stephane G.,Hughes, Greg
supporting information; experimental part, p. 1159 - 1162 (2009/08/07)
A novel two-step procedure for the synthesis of 3-amino-5-substituted- isoxazoles is described. In the presence of a base, readily available 3-bromoisoxazolines react with amines to afford 3-aminoisoxazolines. An oxidation protocol was developed for these heterocycles to provide 3-aminoisoxazoles in consistently high yield.
