1161848-07-2Relevant academic research and scientific papers
Catalytic asymmetric synthesis of both enantiomers of pyrrolizidines 223H', 239K', 265H', and 267H' found in madagascan frogs (Mantella) and their affinities for nicotinic acetylcholine receptor
Saito, Yukako,Takahashi, Seiki,Azer, Nehad,Eldefrawi, Amira T.,Eldefrawi, Mohyee E.,Takahata, Hiroki
experimental part, p. 1043 - 1060 (2009/12/26)
The asymmetric synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' has been achieved starting from 1,5-hexadiene via a common synthetic intermediate 5. The affinity of both enanthiomers of 1-4 for nicotinic acetylcholine receptor was evaluated.
