1161876-36-3Relevant academic research and scientific papers
A highly efficient synthesis of 3H-1,5-benzodiazepine derivatives using lanthanum(III) nitrate hexahydrate as a catalyst
Kumar, Rajesh,Joshi
experimental part, p. 1045 - 1049 (2010/03/03)
Sulphonation of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H- pyrazolo[4,3-d]pyrimidin-7-one (1) with chlorosulphonic acid affords 5-[(5-chlorosulphonyl-2-ethoxy)pyrimidin]-1-methyl-3-propyl-1, 6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one (2). Compound (2) condensed with different β-diketones/β-ketoesters (3a-e) to obtain new β-diketones/β-ketoesters (4a-e). These β-diketones/β- ketoesters were condensed with o-phenylenediamine (o-PDA) in presence of lanthanum(III) nitrate hexahydrate to afford biologically active 3H-1,5-benzodiazepines (5a-e) in excellent yield. The compounds (5a-e) have been screened for antimicrobial, antifungal and anthelmintic activities.
