1161880-42-7Relevant articles and documents
Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (irinotecan; CPT-11) toxicity
Hicks, Latorya D.,Hyatt, Janice L.,Stoddard, Shana,Tsurkan, Lyudmila,Edwards, Carol C.,Wadkins, Randy M.,Potter, Philip M.
experimental part, p. 3742 - 3752 (2010/04/05)
CPT-11 is an antitumor prodrug that is hydrolyzed by carboxylesterases (CE) to yield SN-38, a potent topoisomerase I poison. However, the dose limiting toxicity delays diarrhea that is thought to arise, in part, from activation of the prodrug by a human i