1161925-98-9Relevant articles and documents
Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia
Valdez, Carlos A.,Tripp, Jonathan C.,Miyamoto, Yukiko,Kalisiak, Jaroslaw,Hruz, Petr,Andersen, Yolanda S.,Brown, Sabrina E.,Kangas, Karina,Arzu, Leo V.,Davids, Barbara J.,Gillin, Frances D.,Upcroft, Jacqueline A.,Upcroft, Peter,Fokin, Valery V.,Smith, Diane K.,Sharpless, K. Barry,Eckmann, Lars
experimental part, p. 4038 - 4053 (2009/12/28)
Infections with the diarrheagenic pathogen, Giardia lamblia, are commonly treated with the 5-nitroimidazole (5-NI) metronidazole (Mz), and yet treatment failures and Mz resistance occur. Using a panel of new 2-ethenyl and 2-ethanyl 5-NI derivatives, we fo