116193-58-9Relevant academic research and scientific papers
Method for lowering plasma levels of lipoprotein (a)
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, (2008/06/13)
Retinoids are effective to lower plasma levels of Lp (a) in mammals.
Pharmaceutical or cosmetic composition containing a combination of a retinoid and a sterol
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, (2008/06/13)
PCT No. PCT/FR91/00526 Sec. 371 Date Mar. 2, 1993 Sec. 102(e) Date Mar. 2, 1993 PCT Filed Jul. 2, 1991 PCT Pub. No. WO92/00076 PCT Pub. Date Jan. 9, 1992A pharmaceutical or cosmetic composition comprising in combination, a retinoid and a sterol inhibits the biosynthesis of cholesterol, is disclosed wherein a synergistic effect, principally in the treatment of disorders of epidermic keratinization, disorders of epidermic or epithelial proliferation and/or disorders of sebaceous function, is exhibited.
Retinobenzoic Acids. 1. Structure-Activity Relationships of Aromatic Amides with Retinoidal Activity
Kagechika, Hiroyuki,Kawachi, Emiko,Hashimoto, Yuichi,Himi, Toshiyuki,Shudo, Koichi
, p. 2182 - 2192 (2007/10/02)
Two types of aromatic amides, terephthalic monoanilides and (arylcarboxamido)benzoic acids, have been shown to possess potent retinoidal activities and can be classified as retinoids.The structure-activity relationships of these amides are discussed on the basis of differentiation-inducing activity on human promyelocytic leukemia cells HL-60.In generic formula 4 (X = NHCO or CONH), the necessary factors to elicit the retinoidal activities are a medium-sized alkyl group (isopropyl, tert-butyl, etc.) at the meta position and a carboxyl group at the para position of the other benzene ring.The bonding of the amide structure can be reversed, this moiety apparently having the role of locating the two benzene rings at suitable positions with respect to each other.Substitution at the ring position ortho to the amide group or N-methylation of the amido group caused loss of activity, presumably owing to the resultant change of conformation.It is clear that the mutual orientation of the benzylic methyl group(s) and the carboxyl group and their distance apart are essential factors determining the retinoidal activity.Among the synthesized compounds, 4-benzoic acid (Am80) and 4-benzoic acid (Am580) were several times more active than retinoic acid in the assay.They are structurally related to retinoic acid, as is clear from the biological activity of the hybrid compounds (M2 and R2).
