116198-48-2Relevant academic research and scientific papers
An Improved Synthesis of the Antibiotic Dehydrophos
Jiménez-Andreu, M. Mercedes,Sayago, Francisco J.,Cativiela, Carlos
, p. 3965 - 3973 (2018/07/31)
Within this work an efficient procedure for the synthesis of the vinyl phosphonate tripeptide dehydrophos is described. This procedure constitutes a significant improvement over previously described strategies, since critical transformations in the synthesis of dehydrophos were carried out in only two synthetic steps, with higher yields and under smooth conditions. Thus, the dehydrophosphoalanine residue was generated by means of the Horner–Wadsworth–Emmons reaction of formaldehyde with a peptide bearing an aminomethylbis(phosphonate) moiety, whereas deprotection of the N-terminal position of the thus-obtained dehydrophosphonopeptide and partial hydrolysis of the dimethyl phosphonate residue took place simultaneously. In addition, we confirmed that the chiral integrity of the leucine residue was preserved throughout these transformations.
Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid
Whitteck, John T.,Ni, Weijuan,Griffin, Benjamin M.,Eliot, Andrew C.,Thomas, Paul M.,Kelleher, Neil L.,Metcalf, William W.,Van Der Donk, Wilfred A.
, p. 9089 - 9092 (2008/09/20)
(Chemical Equation Presented) Third time's the charm! The structure of the phosphonate antibiotic A53868, first isolated in 1983 from Streptomyces luridus, has proven quite elusive. Originally reported as 1 and later revised to 2, the actual structure of
