116199-39-4

Basic information

• Product Name: Benzenepropanol, a-methyl-, 4-methylbenzenesulfonate, (S)-
• CAS NO: 116199-39-4
• Molecular Formula: C17H20O3S
• Molecular Weight: 304.41
• Mol File: 116199-39-4.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzenepropanol, a-methyl-, 4-methylbenzenesulfonate, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanol, a-methyl-, 4-methylbenzenesulfonate, (S)-(116199-39-4)
• EPA Substance Registry System: Benzenepropanol, a-methyl-, 4-methylbenzenesulfonate, (S)-(116199-39-4)

Safety Data

• Hazardous Substances Data: 116199-39-4(Hazardous Substances Data)

Upstream product

• 1589-82-8 phenylmagnesium bromide 
• 6921-34-2 benzylmagnesium chloride 
• 2344-70-9 (+)-(S)-4-phenylbutan-2-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 2344-70-9 1-phenyl-3-butanol 

Downstream Products

• 132665-55-5 1-(3-fluorobutyl)benzene 
• 122445-14-1 (3-cyclohexylbutyl)benzene 
• 80651-37-2 (R)-(-)-2-methyl-4-phenylbutyric acid 
• 1071001-86-9 1-(morpholin-4-yl)-5-phenylpentan-1-one 
• 2832-95-3 4-(4-phenylbutan-2-yl)morpholine 

Relevant articles and documents

Stereospecific Nickel-Catalyzed Reductive Cross-Coupling of Alkyl Tosylate and Allyl Alcohol Electrophiles

The stereospecific cross-coupling of easily accessed electrophiles holds significant promise in the construction of C-C bonds. Herein, we report a nickel-catalyzed reductive coupling of allyl alcohols with chiral, nonracemic alkyl tosylates. This cross-coupling delivers valuable allylation products with high levels of stereospecificity across a range of substrates. The catalytic system consists of a simple nickel salt in conjunction with a commercially available reductant and importantly represents a rare example of a cross-coupling involving the C-O bonds of two electrophiles.

Preparation method of labetalol hydrochloride

The invention provides a preparation method of labetalol hydrochloride, and belongs to the technical field of medicines. The invention provides a preparation method. The method comprises the following steps: carrying out nucleophilic substitution reaction on 5-halogenated acetyl salicylamide serving as an initial raw material and benzylamine, and then carrying out nucleophilic substitution reaction on the obtained product and 3-halogenated butylbenzene (or carrying out amine-ester exchange reaction on the obtained product and an esterification reaction product of 3-hydroxybutylbenzene and p-toluenesulfonyl chloride); and carrying out catalytic hydrogenation reaction and salifying to obtain the labeolol hydrochloride. According to the preparation method provided by the invention, benzylamine is adopted to replace dibenzylamine, so that the raw materials are high in atom utilization rate and environment-friendly, and atom economy of green chemistry is embodied; wherein the amine-ester exchange reaction is high in selectivity, and the obtained product is directly used for the next-step reaction. The one-step method is adopted to remove the protective agent and reduce carbonyl, so that the process route is shortened; meanwhile, the preparation method is simple and convenient to operate, high in stability and controllability, high in production cost, high in yield and suitable for industrial production.

Cobalt-Catalyzed Aminocarbonylation of Alkyl Tosylates: Stereospecific Synthesis of Amides

Metal-catalyzed aminocarbonylation is a standard approach for installing amide functionality in chemical synthesis. Despite broad application of this transformation using aryl or vinyl electrophiles, there are few examples involving unactivated aliphatic substrates. Furthermore, there are no stereocontrolled aminocarbonylations of alkyl electrophiles known. Herein, we report a stereospecific aminocarbonylation of unactivated alkyl tosylates for the synthesis of enantioenriched amides. This cobalt-catalyzed transformation uses a remarkably broad range of amines and proceeds with excellent stereospecificity and chemoselectivity.