1162120-35-5 Usage
General Description
3-(5-chloro-2-phenoxyphenyl)-1-methylpyrrolidine-2,4-dione, also known as ticlopidine, is a chemical compound that belongs to the class of thienopyridines. It is a platelet aggregation inhibitor that has antithrombotic properties and is used in the prevention of stroke and heart attacks in patients with a history of these conditions. Ticlopidine works by inhibiting the binding of adenosine diphosphate (ADP) to its platelet receptor, thereby preventing platelet aggregation and reducing the risk of clot formation. It is also used in combination with aspirin in patients undergoing coronary stent placement to reduce the risk of stent thrombosis. However, ticlopidine is associated with several side effects, including neutropenia and thrombotic thrombocytopenic purpura, which has led to the development of newer antiplatelet agents with better safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 1162120-35-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,2,1,2 and 0 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1162120-35:
(9*1)+(8*1)+(7*6)+(6*2)+(5*1)+(4*2)+(3*0)+(2*3)+(1*5)=95
95 % 10 = 5
So 1162120-35-5 is a valid CAS Registry Number.
1162120-35-5Relevant articles and documents
Debottlenecking the Synthesis Route of Asenapine
Van Der Linden, Marco,Roeters, Theo,Harling, Ramon,Stokkingreef, Edwin,Gelpke, Arjan Sollewijn,Kemperman, Gerjan
, p. 196 - 201 (2008)
The discovery synthesis of asenapine that was used for the manufacture of drug substance batches up to 10 kg contained two chemical steps that were major bottlenecks for scale-up. One of these steps involved a magnesium/methanol reduction of an enamide moiety that was severely hampered by safety and efficiency problems. The other step was a laborious chromatography and isomerization cycle that was marked by a poor yield and extremely low throughput The safety issues of the magnesium/methanol reduction could be solved by adding portions of magnesium to a solution of the enamide. In addition, an alternative process for the conversion of the mixture of cis- and trans-lactam into the desired trans-isomer was developed, circumventing the chromatographic separation.
