1162257-36-4Relevant articles and documents
METHOD FOR PRODUCING OPTICALLY ACTIVE 2-PYRROLIDONE COMPOUND
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Paragraph 0071, (2021/05/07)
PROBLEM TO BE SOLVED: To provide a novel method for producing an optically active 2-pyrrolidone compound useful as a pharmaceutical intermediate. SOLUTION: The present invention relates to a novel production method to obtain an optically active 2-pyrrolidone compound of formula (1-R-R) efficiently and highly selectively by causing a ketone compound of formula (3-R) to react with an ammonium salt and a hydrogen gas in the presence of an optically active ruthenium complex catalyst. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2021,JPOandINPIT