116247-46-2

Usage

Uses

Used in Medicinal Chemistry:
1,2,4-Triazin-6(1H)-one, 2,5-dihydro-3-phenyl-5-(phenylmethylene)is used as a pharmaceutical intermediate for the development of new drugs. Its unique structure and biological activity make it a promising candidate for the treatment of various diseases.
Used in Agricultural Chemistry:
In the agricultural sector, 1,2,4-Triazin-6(1H)-one, 2,5-dihydro-3-phenyl-5-(phenylmethylene)is used as a chemical intermediate for the synthesis of agrochemicals, such as pesticides and herbicides, to improve crop protection and yield.
Used as a Dye and Pigment Intermediate:
1,2,4-Triazin-6(1H)-one, 2,5-dihydro-3-phenyl-5-(phenylmethylene)is utilized as an intermediate in the production of dyes and pigments, contributing to the coloration and stability of various materials in industries such as textiles, plastics, and paints.
Used in Cancer Research:
1,2,4-Triazin-6(1H)-one, 2,5-dihydro-3-phenyl-5-(phenylmethylene)is used as an apoptosis inducer in cancer cells, making it a valuable tool in cancer research and drug development. Its ability to induce programmed cell death in cancer cells can potentially lead to the discovery of novel anticancer therapies.
Used in Cell Growth Inhibition Studies:
As an inhibitor of cell growth, 1,2,4-Triazin-6(1H)-one, 2,5-dihydro-3-phenyl-5-(phenylmethylene)is employed in research to understand the mechanisms of cell proliferation and identify potential targets for therapeutic intervention in diseases characterized by uncontrolled cell growth.

Upstream product

• 842-74-0 4-benzylidene-2-phenyloxazole-5(4H)-one 
• 130814-94-7 (Z)-N-(3-hydrazinyl-3-oxo-1-phenylprop-1-en-2-yl)benzamide 
• 17606-70-1 (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 

Relevant academic research and scientific papers

Reactivity of Z- and E-isomers of 2-benzamido-3-phenylacrylohydrazide towards some carbon electrophiles. A comparative study

Z- and E-isomers of 2-benzamido-3-phenylacrylohydrazide 2a, 2b have different relative reactivities towards some carbon electrophiles had been discussed.The Z-isomer underwent cyclization to give imidazole derivative 3 and triazine derivative 4, whereas the latter E-isomer does not undergo such cyclization. The reaction of 2a and/or 2b with 1,2-dibenzylidene hydrazine at different reaction conditions afforded the Schiff bases 6, 8 and the triazolidine derivative 9. Reactions of 2a, 2b with formic acid and phthalic anhydride gave the different cyclization products 10–14, respectively. The structures of all the new synthesized compounds were established from their IR, 1H-NMR and mass spectra as well as elemental analyses.

Utility of 4-Benzylidene-2-phenyl-5(4H)-oxazolone in Synthesis of Triazine, Oxadiazole and Imidazole Derivatives of Anticipated Biological Activity

Treatment of oxazolone 1 with hydrazine hydrate at room temperature gave the (Z)-configurated isomer hydrazide (Z)-3 (high yield). However, refluxing 1 with hydrazine hydrate yielded the (E)-configurated isomer hydrazide (E)-2 (low yield).The hydrazide derivative (Z)-3 has been utilized as synthon for the synthesis of 1,2,4-triazinone, imidazolone, and oxadiazole derivatives through appropriate routes. The thiosemicarbazide and semicarbazide derivatives are synthesized by different routes. The structures of the new compounds were established on the basis of IR, 1H-NMR, mass spectral data, and elemental analysis.

Hydrazinolysis of Unsaturated Azlactones and Cyclisation of the Acrylic Acid Hydrazides into Tetrahydrotriazine, Pyrazolidine and Imidazoline Derivatives

Hydrazinolysis of 4-arylmethylene-2-oxazolin-5-ones (1) gives the corresponding acrylic acid hydrazides (5) among which the N-substituted hydrazides (5; R2=H) afford 5-aryl-methylene-3-phenyl-1,2,5,6-tetrahydro-1,2,4-triazin-6-ones (8) on heating with aq. sodium hydroxide and with excess of hydrazine hydrate, respectively.However, the N-phenylhydrazides (5; R2=Ph) give the corresponding 1-anilinio-4-arylmethylene-2-phenyl-2-imidazolin-5-ones (9) by simple heating.All steps can be carried out in the same flask.