116264-32-5

Upstream product

• 73058-30-7 (2S)-2-benzylazacyclopropane 
• 7783-06-4 hydrogen sulfide 
• 3182-95-4 L-Phenylalaninol 
• 283589-06-0 (S)-1-(bromomethyl)-2-phenylethylammonium bromide 

Downstream Products

• 118387-86-3 2-((S)-2-Amino-3-phenyl-propylsulfanyl)-3-phenyl-propionic acid tert-butyl ester 
• 118388-50-4 ((S)-1-Benzyl-2-{1-[(S)-1-((S)-2-{(S)-1-[(S)-1-((S)-2-benzylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethylcarbamoyl}-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethanesulfinyl}-ethyl)-carbamic acid tert-butyl ester 
• 118388-47-9 (3S,4S)-3-Hydroxy-6-methyl-4-{2-[(S)-2-(3-methyl-butyrylamino)-3-phenyl-propane-1-sulfonyl]-3-phenyl-propionylamino}-heptanoic acid {(S)-1-[(S)-1-((S)-2-benzylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethyl}-amide 
• 118388-48-0 Iva-PheΨPhe-Sta-Ala-Sta-NHCH2Ph 
• 118388-46-8 (3S,4S)-3-Hydroxy-6-methyl-4-{2-[(S)-2-(3-methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionylamino}-heptanoic acid {(S)-1-[(S)-1-((S)-2-benzylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethyl}-amide 
• 118405-16-6 [(S)-1-Benzyl-2-(1-{(S)-1-[(S)-2-((S)-1-benzylcarbamoyl-3-methyl-butylcarbamoyl)-1-hydroxy-ethyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethanesulfinyl)-ethyl]-carbamic acid tert-butyl ester 
• 124339-15-7 Iva-PheΨGly-Sta-Leu-NHCH2Ph 
• 118387-87-4 2-[(S)-2-(3-Methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionic acid tert-butyl ester 
• 118387-93-2 2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propane-1-sulfinyl)-3-phenyl-propionic acid 
• 118387-89-6 2-[(S)-2-(3-Methyl-butyrylamino)-3-phenyl-propane-1-sulfinyl]-3-phenyl-propionic acid 
• 84765-20-8 2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propylsulfanyl)-3-phenyl-propionic acid 
• 118387-88-5 2-[(S)-2-(3-Methyl-butyrylamino)-3-phenyl-propylsulfanyl]-3-phenyl-propionic acid 
• 118404-38-9 [(S)-2-(3-Methyl-butyrylamino)-3-phenyl-propylsulfanyl]-acetic acid 

Relevant academic research and scientific papers

Properties and Reactions of Substituted 1,2-Thiazetidine 1,1-Dioxides: Chiral Mono- and Bicyclic 1,2-Thiazetidine 1,1-Dioxides from α-Amino Acids

New chiral mono- and bicyclic β-sultams, valuable building blocks for drug synthesis, have been prepared from L-Ala, L-Val, L-Leu, L-Ile, L-Phe, L-Cys, L-Ser, L-Thr, and D-penicillamine by transformation of the COOH group into a methylsulfonyl chloride function, followed by cyclization under basic conditions. Selected properties, derivatives, and reactions of the β-sultams are described.

Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites

Renin inhibitors having 13 different isosteres connecting the P3 and P2 positions have been prepared. Synthetic routes and in vitro activity exhibited by these compounds are discussed. The two most potent compounds, 47 and 48, contai

RENIN INHIBITORS

The invention concerns novel renin-inhibitory peptides which are useful for treating renin associated hypertension and for treating hyperaldosteronism. Novel intermediates, processes for preparing both the intermediates and the novel peptides, pharmaceutical compositions, and methods of treatment are included.