1162662-54-5Relevant articles and documents
One-pot enantioselective synthesis of 3-nitro-2H-chromenes catalyzed by a simple 4-hydroxyprolinamide with 4-nitrophenol as cocatalyst
Yin, Guohui,Zhang, Richeng,Li, Lei,Tian, Jun,Chen, Ligong
, p. 5431 - 5438 (2013/09/02)
The asymmetric domino oxa-Michael-Henry reaction of salicylaldehyde derivatives with trans-β-nitro olefins catalyzed by a readily available trans-4-hydroxy-L-prolinamide with 4-nitrophenol as an effective cocatalyst is presented. The corresponding 3-nitro
A novel enantioselective catalytic tandem oxa-Michael-Henry reaction: One-pot organocatalytic asymmetric synthesis of 3-nitro-2H-chromenes
Xu, Dan-Qian,Wang, Yi-Feng,Luo, Shu-Ping,Zhang, Shuai,Zhong, Ai-Guo,Chen, Hui,Xu, Zhen-Yuan
supporting information; experimental part, p. 2610 - 2616 (2009/09/07)
An enantioselective oxa-Michael-Henry reaction of substituted salicylaldehydes with nitroolefins that proceeds though an aromatic iminium activation (AIA) has been developed by using a chiral secondary amine organocatalyst and salicylic acid as a co-catalyst. The corresponding 3-nitro-2H-chromenes were obtained in moderate-to-good yields with up to 91% ee under mild conditions. Based on the experimental results and ESI-mass spectrometric detection of the intermediates, a plausible transition state has been proposed to explain the origin of the activation and the asymmetric induction.
