1162663-33-3Relevant academic research and scientific papers
De novo asymmetric approach to 8a-epi-Swainsonine
Coral, Jason A.,Guo, Haibing,Shan, Mingde,O'Doherty, George A.
, p. 521 - 529 (2009)
An improved method for the synthesis of (-)-8a-epi-swainsonine has been developed with 9 fewer steps than the original route. The synthetic improvements include a two-step procedure for the preparation of benzyl 4-(furan-2-yl)-4-oxobutylcarbamate from pyr
De novo asymmetric synthesis of 8a-epi-swainsonine
Abrams, Jason N.,Babu, Ravula Satheesh,Guo, Haibing,Le, Dianna,Le, Jennifer,Osbourn, Joshua M.,O'Doherty, George A.
, p. 1935 - 1940 (2008/09/18)
(Chemical Equation Presented) An enantioselective and diastereocontrolled approach to 8a-epi-D-swainsonine has been developed from achiral furfural. The key step to this synthesis was a one-pot procedure for the hydrogenolytic removal of two protecting groups and two intramolecular reductive amination reactions. The absolute stereochemistry was introduced by asymmetric Noyori reduction of furfuryl ketone. This route relies on diastereoselective palladium-catalyzed glycosylation to install the anomeric bond, and Luche reduction, diastereoselective dihydroxylation to set up the manno- stereochemistry of the indolizidine precursor.
