116290-73-4

Upstream product

• 110-85-0 piperazine 
• 824-75-9 p-fluorobenzamide 
• 68104-63-2 N-(4-cyanophenyl)piperazine 

Downstream Products

• 170858-28-3 (RS)-4-[4-[(Isochroman-1-yl)methyl]piperazin-1-yl]benzamide maleate 
• 182180-10-5 4-[4-[(Imidazo[1,2-a]pyridin-2-yl)methyl]-1-piperazinyl]-benzamide 
• 182180-24-1 4-[4-[(7-Methylimidazo[1,2-a]pyridin-2-yl)methyl]-1-piperazinyl]benzamide 
• 182180-62-7 4-[4-[(6,8-Dichloroimidazo[1,2-a]pyridin-2-yl)methyl]-1-piperazinyl]benzamide 
• 140478-91-7 4-[4-[2-(3-methyl-2-oxazolidinon-5-yl)ethyl]-1-piperazinyl]benzamide 
• 794485-97-5 3-{4-[4-(carbamoylphenyl)piperazin-1-yl]butyl}-1H-indole-5-carboxylic acid 
• 765273-10-7 methyl 3-{4-[4-(carbamoylphenyl)piperazin-1-yl]butyl}-1H-indole-5-carboxylate 
• 117518-32-8 4-[4-(aminocarbonyl)phenyl]-N-[2-(dimethylamino)ethyl]-1-piperazinecarboxamide 

Relevant academic research and scientific papers

Solid phase synthesis of aryl amines via palladium catalyzed amination of resin-bound aromatic bromides

Polymer-bound aromatic bromides were found to readily undergo Pd-catalyzed amination with a number of primary and secondary alkyl- and arylamines to give, after cleavage from the support, a variety of arylamine products.

Having inhibitory anti-apoptosis protein active compound and its preparation and use (by machine translation)

The present invention has offered a kind of inhibiting anti-apoptosis protein active compound and its preparation and use. In particular, the invention provides a compound of formula I the following; wherein the definition of each group as described in the specification. The compounds of the invention has very good Bcl - 2 family protein inhibitory activity, can be used for preparing a series of treating Bcl - 2 family protein activity associated with the disease. (by machine translation)

BENZAMIDE DERIVATIVES

A compound represented by formula (1): wherein X is a single bond or a substituted or unsubstituted lower alkylene group; Z is a saturated or unsaturated monocyclic hydrocarbon ring group or the like; and each of R1, R2, R3 and R4, which may be the same or different, is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a carboxyl group, a substituted or unsubstituted alkyl group, or the like, a prodrug of said compound, or a pharmaceutically acceptable salt of said compound or prodrug has inhibitory effect on Rho kinase and hence is useful for treating diseases which are such that morbidity due to them is expected to be improved by inhibition of Rho kinase and secondary effects such as inhibition of the Na+/H+ exchange transport system caused by the Rho kinase inhibition, for example, hypertension.

IMIDAZO[1,2-A]PYRIDINES FOR THE TREATMENT OF CNS AND CARDIAC DISEASES

The present invention relates to imidazo[1,2-a]pyridine compounds of formula (1) STR1 which are dopamine D-4 antagonists and useful as anti-psychotic agents.

Series of 5-[-(4-aryl-1-piperazinyl)alkyl]-2-oxazolidinone derivatives useful in the treatment of allergic conditions

A method of treating allergic disorders and pharmaceutical compositions therefore are disclosed for a series of 5-[(4-aryl-1-piperazinyl)alkyl]-2-oxazolidinone derivatives of Formula I. These compounds are useful in inhibiting Type I allergic STR1 responses in a living animal and thus can be used to treat allergic phenomena such as asthma, rhinitis, atopic dermatitis, chronic hives, allergic conjunctivitis and the like.