116297-10-0

Basic information

• Product Name: (R)-2-Hydroxyheptanenitrile
• Synonyms: (R)-2-Hydroxyheptanenitrile
• CAS NO: 116297-10-0
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.18
• Mol File: 116297-10-0.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-2-Hydroxyheptanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Hydroxyheptanenitrile(116297-10-0)
• EPA Substance Registry System: (R)-2-Hydroxyheptanenitrile(116297-10-0)

Safety Data

• Hazardous Substances Data: 116297-10-0(Hazardous Substances Data)

Usage

General Description

(R)-2-Hydroxyheptanenitrile, also known as (R)-2-hydroxyheptyolonitrile, is a chemical compound with the molecular formula C7H15NO. It is a colorless liquid with a minty odor, and it is used as a flavoring agent and fragrance ingredient. It is a chiral molecule, meaning it has a non-superimposable mirror image, and the (R)-enantiomer is the natural form of the compound. (R)-2-Hydroxyheptanenitrile is commonly found in food and pharmaceutical products, and it is also used in the production of perfumes and other consumer goods. It is important to note that this chemical may have potential health hazards and should be handled with care according to safety guidelines.

Upstream product

• 74-90-8 hydrogen cyanide 
• 66-25-1 hexanal 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 4111-12-0 (+/-)-2-methyl-2-hydroxyhexanenitrile 
• 40326-17-8 2-Trimethylsilanyloxy-heptanenitrile 
• 52358-06-2 2-hydroxyheptanenitrile 

Downstream Products

• 93292-63-8 (S)-2-(tert-butyldiphenylsilyloxy)heptanal 
• 1610457-89-0 C₂₃H₃₁NOSi 
• 1585968-98-4 [(5R,6R)-5-(methoxymethoxy)undec-1-en-6-yloxy](tert-butyl)diphenylsilane 
• 1585968-97-3 [(5S,6R)-5-(methoxymethoxy)undec-1-en-6-yloxy](tert-butyl)diphenylsilane 
• 128142-68-7 (S)-2-(tert-butyldiphenylsilyloxy)heptanal 

Relevant articles and documents

Approach to (R)- and (S)-ketone cyanohydrins using almond and apple meal as the source of (R)-oxynitrilase

The synthesis of aliphatic and aromatic (R)-ketone cyanohydrins through the addition of hydrogen cyanide to the corresponding ketones and the synthesis of the (S)-enantiomers through the kinetic resolution of racemic ketone cyanohydrins has been studied in the presence of almond or apple meal. Substrate tolerance of the (R)-oxynitrilases towards ketones (R1R2C=O) is highly restricted compared to that of structurally similar aldehydes, reactivity following the order of H>Me>>Et for R2. In the case of aromatic methyl ketones reactivity difference (C6H5>>p-Me-C6H4 for R1) is notable.

Fusion of a Coiled-Coil Domain Facilitates the High-Level Production of Catalytically Active Enzyme Inclusion Bodies

The increasing number of biocatalytic reactions implemented in chemical synthesis routes raises the urgent need for large amounts of enzymes. Hence, new generic methods are required for their simple and cost-efficient production. Here, we describe a gener

Chemoenzymatic asymmetric total synthesis of nonanolide (Z)-cytospolides D, E and their stereoisomers

Chemoenzymatic asymmetric total synthesis of the (Z)-isomer of the naturally occurring decanolide cytospolides D, E and six stereoisomers is reported. The main highlight of the synthetic venture involves ring-closing metathesis (RCM) reaction of a suitably functionalized ester compound, which was assembled by the Yamaguchi coupling of the required acid and alcohol fragments. The alcohol fragment was ac- cessed by two alternative chemoenzymatic processes, one being hydroxynitrile lyase mediated hydrocyanation, whereas lipase-catalyzed transesterification was the key sep in the second route. The acid fragment was constructed by an enantioselective enzymatic desymmetrization (EED) of prochiral 2-methyl-1,3-propanediol and Corey-Bakshi-Shibata (CBS) mediated stereoselective carbonyl reduction.