116299-57-1Relevant academic research and scientific papers
General synthesis route to benanomicin-pradimicin antibiotics
Tamiya, Minora,Ohmori, Ken,Kitamura, Mitsuru,Kato, Hirohisa,Arai, Tadamasa,Oorui, Mami,Suzuki, Keisuke
, p. 9791 - 9823 (2008/09/18)
A general approach to the regio- and stereoselective total synthesis of the benanomicin-pradimicin antibiotics (BpAs) is described. Construction of the aglycon has been achieved by 1)the diastereoselective ring-opening of a biaryl lactone by using (R)-val
Regio- and stereocontrolled total synthesis of benanomicin B
Ohmori, Ken,Tamiya, Minoru,Kitamura, Mitsuru,Kato, Hirohisa,Oorui, Mami,Suzuki, Keisuke
, p. 3871 - 3874 (2007/10/03)
(Chemical Equation Presented) Fully controlled total synthesis of benanomicin B was achieved by exploiting two key steps : a stereocontrolled ring-opening of a lactone (see scheme, step A), and a semipinacol cyclization of an acetal-aldehyde derivative discriminating the two hydroxy groups of the pseudo-C2-symmetric 1,2-diol moiety (step B).
