116308-60-2

Basic information

• Product Name: 2-Butenedioic acid, 2-(4-morpholinyl)-, diethyl ester, (E)-
• CAS NO: 116308-60-2
• Molecular Formula: C12H19NO5
• Molecular Weight: 257.287
• Mol File: 116308-60-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Butenedioic acid, 2-(4-morpholinyl)-, diethyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenedioic acid, 2-(4-morpholinyl)-, diethyl ester, (E)-(116308-60-2)
• EPA Substance Registry System: 2-Butenedioic acid, 2-(4-morpholinyl)-, diethyl ester, (E)-(116308-60-2)

Safety Data

• Hazardous Substances Data: 116308-60-2(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 24736-85-4 diethyl 7-oxabicyclo[2.2.1]hepta-2⁽³⁾,5⁽⁶⁾-diene-2,3-dicarboxylate 

Downstream Products

• 1552282-95-7 ethyl 2-(3-ethoxy-2-morpholino-3-oxoprop-1-en-1-yl)benzoate 
• 105151-48-2 diethyl 5-methylpyridine-2,3-dicarboxylate 

Relevant articles and documents

A facile synthesis of β-amino carbonyl compounds through an aza-Michael addition reaction under solvent-free conditions

An efficient and eco-friendly process for the synthesis of β-amino carbonyl compounds was introduced in this paper. The oxanorbornene β-amino esters and β-enamine esters were successfully prepared from oxabornene and amines by using solvent-free aza-Michael addition reaction in the absence of any catalyst. Oxanorbornene β-amino esters were the major product at room temperature, but higher temperature (e.g. 90 °C) led to the formation of β-enamine esters. In addition, all of the target compounds were characterized by IR, 1H NMR, 13C NMR, and HR-MS. A possible reaction pathway was also proposed.