1163123-05-4

Basic information

• Product Name: (5-methyl-2-trifluoromethyl-phenyl)-[(R)-3-(2-phenyl-pyrimidin-4-ylamino)-pyrrolidin-1-yl]-methanone
• Synonyms: (5-methyl-2-trifluoromethyl-phenyl)-[(R)-3-(2-phenyl-pyrimidin-4-ylamino)-pyrrolidin-1-yl]-methanone
• CAS NO: 1163123-05-4
• Molecular Weight: 426.441
• Mol File: 1163123-05-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (5-methyl-2-trifluoromethyl-phenyl)-[(R)-3-(2-phenyl-pyrimidin-4-ylamino)-pyrrolidin-1-yl]-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (5-methyl-2-trifluoromethyl-phenyl)-[(R)-3-(2-phenyl-pyrimidin-4-ylamino)-pyrrolidin-1-yl]-methanone(1163123-05-4)
• EPA Substance Registry System: (5-methyl-2-trifluoromethyl-phenyl)-[(R)-3-(2-phenyl-pyrimidin-4-ylamino)-pyrrolidin-1-yl]-methanone(1163123-05-4)

Safety Data

• Hazardous Substances Data: 1163123-05-4(Hazardous Substances Data)

Upstream product

• 14790-42-2 4-chloro-2-phenylpyrimidine 
• 1163123-47-4 ((R)-3-amino-pyrrolidin-1-yl)-(5-methyl-2-trifluoromethyl-phenyl)-methanone 

Relevant articles and documents

HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

The present invention relates to compounds of formula wherein Ar, Het, R1 and n are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and are useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder and sleep disorders associated with neurological diseases.