116314-86-4

Basic information

• Product Name: 2,3-dihydroxy-5-nitrobenzonitrile
• CAS NO: 116314-86-4
• Molecular Formula: C₇H₄N₂O₄
• Molecular Weight: 180.1177
• Mol File: 116314-86-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 384.9°C at 760 mmHg
• Flash Point: 186.6°C
• Density: 1.69g/cm³
• Vapor Pressure: 1.79E-06mmHg at 25°C
• Refractive Index: 1.683
• CAS DataBase Reference: 2,3-dihydroxy-5-nitrobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydroxy-5-nitrobenzonitrile(116314-86-4)
• EPA Substance Registry System: 2,3-dihydroxy-5-nitrobenzonitrile(116314-86-4)

Safety Data

• Hazardous Substances Data: 116314-86-4(Hazardous Substances Data)

Upstream product

• 22802-78-4 2-cyano-6-methoxy-4-nitrophenol 
• 52924-54-6 2,3-dihydroxy-5-nitro-benzaldehyde 
• 2950-43-8 hydroxylamine-O-sulfonic acid 

Relevant articles and documents

Catechol derivatives

Catechol derivatives of the formula STR1 wherein Ra, Rb and Rc have the significance given herein, the ester and ether derivatives thereof which are hydrolyzable under physiological conditions and the pharmaceutically acceptable salts thereof are described and possess valuable pharmacological properties. In particular, they inhibit the enzyme catechol-O-methyltransferase (COMT), a soluble, magnesium-dependent enzyme which catalyses the transference of the methyl group of S-adensoylmethionine to a catechol substrate, whereby the corresponding methyl ethers are formed. Suitable substrates which can be O-methylated by COMT and which can thus be deactivated are, for example, extraneuornal catecholamines and exogeneously-administered therapeutically active substances having a catechol structure. Formula Ia above embraces not only compounds which form part of the invention, but also known compounds; the compounds which form part of the invention can be prepared according to known methods.