1163141-31-8

Basic information

• Product Name: 3-amino-5-(trifluoromethoxy)benzoic acid
• Synonyms: 3-amino-5-(trifluoromethoxy)benzoic acid
• CAS NO: 1163141-31-8
• Molecular Weight: 221.136
• Mol File: 1163141-31-8.mol

Chemical Properties

• CAS DataBase Reference: 3-amino-5-(trifluoromethoxy)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-5-(trifluoromethoxy)benzoic acid(1163141-31-8)
• EPA Substance Registry System: 3-amino-5-(trifluoromethoxy)benzoic acid(1163141-31-8)

Safety Data

• Hazardous Substances Data: 1163141-31-8(Hazardous Substances Data)

Upstream product

• 453565-90-7 3-bromo-5-(trifluoromethoxy)benzoic acid 

Downstream Products

• 1573025-02-1 3-((4-((4-(3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)-5-(trifluoromethoxy)benzamide 
• 1573025-67-8 3-amino-N-(2-morpholinoethyl)-5-(trifluoromethoxy)benzamide 

Relevant articles and documents

KINASE INHIBITORS

There are provided compounds of formula I. wherein R1 to R5, X1, X2, Ar, L, A, A1, E and G have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

KINASE INHIBITORS

There are provided compounds of formula (I), wherein R1 to R5, X1, X2, Ar, L, A, A1, E and G have meanings given in the description, which compounds have anti-inflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

KINASE INHIBITORS

There are provided compounds of formula (I), (Formula (I)) wherein R1 to R5, X1, X2, Ar, L, E, A, A1, G and G1 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

TETRAHYDROCYCLOPENTA[B]INDOL-3-YL CARBOXYLIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS

The present invention relates to certain (1,2,4-oxadiazol-3-yl)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl carboxylic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.