116324-72-2Relevant academic research and scientific papers
Preparation and Evaluation of Cold Iodinated Analogs of Calcium Channel Blockers as Potential Myocardial Imaging Agents
El-Moselhy, Tarek,Eldawy, Mohamed A,Hede, Ragnar,Nyberg, Fred
, p. 496 - 501 (2007/10/03)
A group of iodinated calcium channel blockers was synthesized to be investigated as potential myocardial imaging agents. It comprised of diphenylalkylamine calcium antagonists such as the iodinated verapamil analog (1) and a new series of iodinated 1,4-di
1,4-Dihydropyridine antagonist activities at the calcium channel: A quantitative structure-activity relationship approach
Coburn,Wierzba,Suto,Solo,Triggle,Triggle
, p. 2103 - 2107 (2007/10/02)
The effect of 46 1,4-dihydropyridine-type calcium channel antagonists on the tonic contractile response of longitudinal muscle strips of guinea pig ileum was determined. 2,6-Dimethyl-3,5-dicarbomethoxy-4-phenyl-1,4-dihydropyridine (13) and 13 ortho-, 15 meta-, and seven para-monosubstituted and 10 polysubstituted aromatic derivatives of 13 were studied. The pharmacological activities of the monosubstituted derivatives were best correlated by eq 10, log 1/C = 0.68π + 2.50σ(m) - 0.47L(meta) - 3.40B1(para) + 11.31, which had a correlation coefficient of 0.89. The full data set was best correlated by eq 11, log 1/C = 0.62π + 1.96σ(m) - 0.44L(meta) - 3.26B1(para) - 1.51L(meta) + 14.23, which had a correlation coefficient of 0.90. Equations of similar form but involving an ortho steric term were found to correlate the radioligand binding data for this class of compounds.
