116332-62-8

Basic information

• Product Name: N-METHOXY-N-METHYL-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE
• Synonyms: N-METHOXY-N-METHYL-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE;N-Methoxy-N-methyl-3-(trifluoromethyl)benzamide;3-[Methoxy(methyl)carbamoyl]benzotrifluoride
• CAS NO: 116332-62-8
• Molecular Formula: C₁₀H₁₀F₃NO₂
• Molecular Weight: 233.1871096
• Mol File: 116332-62-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-METHOXY-N-METHYL-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHOXY-N-METHYL-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE(116332-62-8)
• EPA Substance Registry System: N-METHOXY-N-METHYL-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE(116332-62-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 116332-62-8(Hazardous Substances Data)

Usage

General Description

N-METHOXY-N-METHYL-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE is a chemical compound commonly used as a building block in the synthesis of pharmaceutical compounds and agrochemicals. It belongs to the class of benzene carboxamides and is characterized by the presence of a trifluoromethyl group attached to the benzene ring. N-METHOXY-N-METHYL-3-(TRIFLUOROMETHYL)BENZENECARBOXAMIDE is known for its high reactivity and plays a crucial role in organic synthesis processes due to its ability to participate in various chemical reactions. It is also used in the production of specialty polymers and materials. Additionally, it is identified as a potential inhibitor of certain enzymes and protein targets, making it a valuable tool in biochemical research.

Upstream product

• 873838-39-2 3-(trifluoromethyl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 13939-06-5 molybdenum hexacarbonyl 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 

Downstream Products

• 842123-89-1 3-[1,3]Dioxolan-2-yl-1-(3-trifluoromethyl-phenyl)-propan-1-one 
• 200801-88-3 2-(2-Methylsulfanylpyrimidin-4-yl)-1-(3-trifluoromethylphenyl)ethanone 
• 146653-56-7 1-(4-cyano)benzyl-1-(3-trifluoromethyl)phenylketone 
• 38675-82-0 cyclopropyl(3-(trifluoromethyl)phenyl)methanone 
• 189442-43-1 L-790,070 
• 188345-22-4 2-pyridin-4-yl-1-(3-trifluoromethyl-phenyl)-ethanone 
• 166312-47-6 4-Oxo-4-(3-trifluoromethyl-phenyl)-butyraldehyde 
• 41819-49-2 2-(3-Trifluoromethyl-phenyl)-1H-pyrrole 
• 189442-58-8 4-[5-(2-fluoropyridin-4-yl)-1-methyl-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-93-0 4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-27-0 (S)-4-[5-[2-(1-phenylethylamino)-pyrimidin-4-yl]-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-25-8 (R)-4-[5-(2-(1-phenylethylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-99-6 (S)-5-<2-(1-phenylethylamino)pyrimidin-4-yl>-1-methyl-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-benzyloxycarbonyl)piperidinyl>imidazole 
• 234767-12-5 (R)-5-<2-(1-phenylethylamino)pyrimidin-4-yl>-1-methyl-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-benzyloxycarbonyl)piperidinyl>imidazole 

Relevant articles and documents

Mo(CO)6 as a Solid CO Source in the Synthesis of Aryl/Heteroaryl Weinreb Amides under Microwave-Enhanced Condition

The facile transformation of aryl/heteroaryl nonaflates into corresponding amides via Pd-catalyzed aminocarbonylation using Mo(CO)6 as a solid CO source under microwave-enhanced condition is reported. The method was found to be tolerant with respect to a

Synthesis of Difluoromethyl Ketones from Weinreb Amides, and Tandem Addition/Cyclization of o-Alkynylaryl Weinreb Amides

[Difluoro(phenylsulfanyl)methyl]trimethylsilane (PhSCF2SiMe3) underwent a fluoride-induced nucleophilic addition to the carbonyl group of Weinreb amides to provide the corresponding difluoro(phenylsulfanyl)methyl ketones. These were

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

A small library of 36 functionalized benzophenone thiosemicarbazone analogs has been prepared by chemical synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B. Inhibitors of cathepsins L and B have the potential to limit or arrest cancer metastasis. The six most active inhibitors of cathepsin L (IC50 50 > 10,000 nM). The most active analog in the series, 3-bromophenyl-2′-fluorophenyl thiosemicarbazone 1, also efficiently inhibits cell invasion of the DU-145 human prostate cancer cell line.