116333-29-0Relevant academic research and scientific papers
Preparation of 2-Arylpropanoic Acids by Oxidative Aryl Migration in (β-Aryl-β-hydroxy)alkyl Phenyl Selenides
Uemura, Sakae,Ohe, Kouichi,Yamauchi, Takayoshi,Mizutaki, Shoichi,Tamaki, Kentaro
, p. 907 - 910 (2007/10/02)
Oxidation of diastereomeric mixtures of 1-aryl-1-hydroxyprop-2-yl phenyl selenides, prepared either by phenylselenylation of propiophenones followed by reduction or by treatment of benzaldehyde with α-(phenylseleno)ethyl anion, with an excess of meta-chloroperbenzoic acid in methanol at 25 deg C for 24 h or at reflux for 2 h affords methyl 2-arylpropanoates almost quantitatively.Similar treatment in tetrahydrofuran at 25 deg C for 24 h results in a direct formation of 2-arylpropanoic acids in high yields.
