116344-68-4Relevant academic research and scientific papers
Studies on pyrrolidinones. On the decarboxylation of pyroglutamic acids and N-acyl prolines in acidic media
Akué-Gédu, Rufine,Al Akoum Ebrik, Sahar,Witczak-Legrand, Anne,Fasseur, Dominique,El Ghammarti, Samira,Couturier, Daniel,Decroix, Bernard,Othman, Mohamed,Debacker, Marc,Rigo, Beno?t
, p. 9239 - 9247 (2002)
During attempted Friedel-Crafts cyclization of some arylmethyl pyroglutamic acids or of N-phenacyl prolines, decomposition of the activated form of the acid have been observed, giving new heterocyclic systems. This general decarboxylation occurred when there are difficulties to realize a Friedel-Crafts cyclization and is explained by geometrical or electronic considerations.
