1163707-54-7 Usage
General Description
1-(4-(2-amino-4-methylthiazol-5-yl)pyridin-2-yl)cyclopropanecarbonitrile is a chemical compound that is used in the pharmaceutical industry for the development of potential drugs and medications. It is a cyclopropanecarbonitrile derivative with a thiazole and pyridine group, making it a versatile building block for the synthesis of various drug candidates. The presence of the amino and methylthiazol groups in its structure indicates its potential for interactions with biological targets, making it a valuable compound for drug discovery and development. This chemical may have potential applications in the treatment of various diseases and conditions, and its unique structure makes it an important molecule for medicinal chemistry research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 1163707-54-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,3,7,0 and 7 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1163707-54:
(9*1)+(8*1)+(7*6)+(6*3)+(5*7)+(4*0)+(3*7)+(2*5)+(1*4)=147
147 % 10 = 7
So 1163707-54-7 is a valid CAS Registry Number.
1163707-54-7Relevant articles and documents
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation
Furet, Pascal,Guagnano, Vito,Fairhurst, Robin A.,Imbach-Weese, Patricia,Bruce, Ian,Knapp, Mark,Fritsch, Christine,Blasco, Francesca,Blanz, Joachim,Aichholz, Reiner,Hamon, Jacques,Fabbro, Doriano,Caravatti, Giorgio
, p. 3741 - 3748 (2013/07/27)
Phosphatidylinositol-3-kinase α (PI3Kα) is a therapeutic target of high interest in anticancer drug research. On the basis of a binding model rationalizing the high selectivity and potency of a particular series of 2-aminothiazole compounds in inhibiting PI3Kα, a medicinal chemistry program has led to the discovery of the clinical candidate NVP-BYL719.
Organic Compounds
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Page/Page column 56, (2009/07/10)
The present invention relates to compounds of formula I and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.