116386-65-3

Basic information

• Product Name: (E)-(2S,3S)-5-((1R,3R,4R)-3-Methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4-dimethyl-3-triethylsilanyloxy-pent-4-enal
• Synonyms: (E)-(2S,3S)-5-((1R,3R,4R)-3-Methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4-dimethyl-3-triethylsilanyloxy-pent-4-enal
• CAS NO: 116386-65-3
• Molecular Weight: 526.948
• Mol File: 116386-65-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-(2S,3S)-5-((1R,3R,4R)-3-Methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4-dimethyl-3-triethylsilanyloxy-pent-4-enal(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(2S,3S)-5-((1R,3R,4R)-3-Methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4-dimethyl-3-triethylsilanyloxy-pent-4-enal(116386-65-3)
• EPA Substance Registry System: (E)-(2S,3S)-5-((1R,3R,4R)-3-Methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4-dimethyl-3-triethylsilanyloxy-pent-4-enal(116386-65-3)

Safety Data

• Hazardous Substances Data: 116386-65-3(Hazardous Substances Data)

Upstream product

• 116386-61-9 (1R,3R,4R)-3-Methoxy-4-triisopropylsilanyloxy-cyclohexanecarbaldehyde 
• 126788-79-2 (S)-4-Benzyl-3-[(E)-3-hydroxy-5-(3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4-dimethyl-pent-4-enoyl]-oxazolidin-2-one 
• 126788-80-5 (E)-(2S,3S)-3-Hydroxy-5-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4-dimethyl-pent-4-enoic acid methoxy-methyl-amide 
• 126788-77-0 (1R,3R,4R)-3-Methoxy-4-triisopropylsilanyloxy-cyclohexanecarboxylic acid methoxy-methyl-amide 
• 116386-60-8 (1R,3R,4R)-3-Hydroxy-4-triisopropylsilanyloxy-cyclohexanecarboxylic acid methoxy-methyl-amide 
• 116386-63-1 (E)-3-((1R,3R,4R)-3-Methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2-methyl-propenal 
• 126788-76-9 (1R,4R,5R)-4-Triisopropylsilanyloxy-6-oxa-bicyclo[3.2.1]octan-7-one 
• 52892-14-5 (1S,3R)-7-Oxa-bicyclo[4.1.0]heptane-3-carboxylic acid 
• 88255-83-8 3,4-Dihydroxycyclohexanecarboxylic acid-γ-lactone 
• 4771-80-6 1,2,5,6-tetrahydrobenzoic acid 
• 116409-60-0 Imidazole-1-carbothioic acid O-((1R,2S,6R,8R)-9-oxo-4-thioxo-3,5,10-trioxa-tricyclo[6.2.1.0^2,6]undec-8-yl) ester 
• 127126-09-4 (1R,3R,4R)-3-Methoxy-4-triisopropylsilanyloxy-cyclohexanecarboxylic acid methoxy-methyl-amide 
• 116386-60-8 (1R,3R,4R)-3-Hydroxy-4-triisopropylsilanyloxy-cyclohexanecarboxylic acid methoxy-methyl-amide 
• 116386-63-1 (E)-2-Methyl-3-<(1R,3R,4R)-3-methoxy-4-<(triisopropylsilyl)oxy>cyclohexyl>-2-propenal 

Downstream Products

• 116386-67-5 (E)-(3S,4R,5S)-7-((1R,3R,4R)-3-Methoxy-4-triisopropylsilanyloxy-cyclohexyl)-4,6-dimethyl-5-triethylsilanyloxy-3-triisopropylsilanyloxy-hept-6-enal 
• 126788-84-9 (E)-(3S,4R,5S)-3-Hydroxy-7-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-4,6-dimethyl-5-triethylsilanyloxy-hept-6-enoic acid methoxy-methyl-amide 
• 126788-85-0 (E)-(3S,4R,5S)-7-((1R,3R,4R)-3-Methoxy-4-triisopropylsilanyloxy-cyclohexyl)-4,6-dimethyl-5-triethylsilanyloxy-3-triisopropylsilanyloxy-hept-6-enoic acid methoxy-methyl-amide 
• 126788-83-8 (S)-4-Benzyl-3-[(E)-(3S,4R,5S)-3-hydroxy-7-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-4,6-dimethyl-5-triethylsilanyloxy-hept-6-enoyl]-oxazolidin-2-one 
• 116386-66-4 (E)-(3S,4R,5S)-3-Hydroxy-7-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-4,6-dimethyl-5-triethylsilanyloxy-hept-6-enoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 126788-82-7 (S)-4-Benzyl-3-[(E)-(2S,3R,4R,5S)-2-chloro-3-hydroxy-7-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-4,6-dimethyl-5-triethylsilanyloxy-hept-6-enoyl]-oxazolidin-2-one 

Relevant articles and documents

Chemistry of tricarbonyl hemiketals and application of Evans' technology to the total synthesis of the immunosuppressant (-)-FK-506

Details of model studies probing the chemistry of the tricarbonyl region of FK-506 are presented, and their use in designing a successful route to this immunosuppressant is outlined. Application of asymmetric oxazolidinone alkylation/aldol methodology to a convergent, highly flexible synthesis of the C10-C18 fragment and to improvements in the preparation of the C20-C34 segment are also discussed.