116386-73-3Relevant academic research and scientific papers
Process for synthesis of FK-506 intermediates
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, (2008/06/13)
A process is described for the synthesis of diastereomeric 2-methyl-4-hydroxy-5-protected-hydroxy-hept-6-en-prolinolamides, which are useful as intermediates in the synthesis of the C10 -C18 chain of the macrolide structure for the immunosuppressant FK-506. These compounds are also useful as intermediates for preparing lactone ultraviolet radiation absorbers.
ALKYLATION OF CHIRAL PROLINOL PROPIONAMIDE ENOLATES WITH EPOXIDES: COMPLETE REVERSAL OF PREDICTED FACIAL SELECTIVITY
Askin, D.,Volante, R. P.,Ryan, K. M.,Reamer, R. A.,Shinkai, I.
, p. 4245 - 4248 (2007/10/02)
The title transformation provided a rapid and efficient synthesis of syn and anti 2-methyl-4-hydroxylcarboxylic ester arrays.
