1164-99-4Relevant articles and documents
Synthesis and Receptor Binding Affinity of 7&α- and 17&α-Substituted 2- and 4-Chloroestradiol Derivatives
Ali, Hasrat,Lier, Johan E. van
, p. 2485 - 2491 (2007/10/02)
Methods for the selective syntheses of 2- and 4-chloroestradiol derivatives substituted at the 17α- and 7α-positions are described.The relative binding affinities for estrogen receptors of these estrogens are also reported, and potential structure-activity relationships are put forth.
Zinc-Acetic Acid Reduction of the Steroid 4-En-3-one: Novel Conversion of the 4-En-3-one into the 2-En-4-one via a Vinyl Chloride
Templeton, John F.,Majid, Samar,Marr, Angelina,Marat, Kirk
, p. 2581 - 2584 (2007/10/02)
Transposition of a steroid 4-en-3-one to the 2-en-4-one has been carried out. 4-Chlorotestosterone acetate on Zn-HOAc reduction yields a mixture of the C-5 epimers of the 4-chloro-3-ene together with a C-3 dimer.The vinyl chlorides, after epoxidation followed by rearrangement and elimination, give the 2-en-4-one.A synthesis of 17β-hydroxy-5α-androst-2-en-4-one and 17β-hydroxy-5α-estr-2-en-4-one is described.
Steroidal imidazole 1 carboxylic acid esters
Fahrenholtz,Boris,Kennedy Jr,Kierstead
, p. 337 - 342 (2007/10/10)
A variety of steroidal esters of imidazole 1 carboxylic acid and related acids was prepared by reaction of the steroidal alcohol with N,N' carbonyldiimidazole or by displacement of phenol from steroid phenylcarbonates. One compound, 21c (the imidazole 1 carboxylate of 19 norethisterone), was found to have an interesting separation of progestational from androgenic activity.