1164115-08-5Relevant academic research and scientific papers
Total synthesis of phoslactomycin A
Koenig, Christian M.,Gebhardt, Bjoern,Schleth, Cornelia,Dauber, Mano,Koert, Ulrich
supporting information; experimental part, p. 2728 - 2731 (2009/12/03)
A convergent total synthesis of the PP2A-inhibitor phoslactomycin A was achieved using a CuTC-mediated coupling of an alkenyl iodide C1-C13 fragment with an C14-C21 alkenyl stannane in the presence of a protected phosphate. Key features for the assembly of the C1-C13 fragment were an asymmetric dihydroxylation, an Evans-Aldol reaction, and a well-balanced protective group strategy. An asymmetric 1,4addition to cyclohexenone was the key step in the preparation of the C14-C21 fragment.
