1164251-80-2Relevant articles and documents
HETEROARYL COMPOUNDS AND USES THEREOF
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, (2014/09/29)
The present invention relates to compounds useful as inhibitors of protein kinases, containing a cysteine residue in the ATP binding site. The invention further provides for pharmaceutically acceptable compositions comprising therapeutically effective amounts of one or more of the protein kinase inhibitor compounds and methods of using said compositions in the treatment of cancers and carcinomas.
2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6
Duan, Hongliang,Zheng, Jin,Lai, Qinglin,Liu, Zheng,Tian, Guanghui,Wang, Zhen,Li, Jianfeng,Shen, Jingshan
supporting information; experimental part, p. 2777 - 2779 (2009/12/31)
In our efforts to minimize the side effects associated with low selectivity against the other PDE isozymes, a novel class of 2-phenylquinazolin-4(3H)-one derivatives were designed and prepared as potent PDE5 inhibitors with high selectivity against PDE6.