116441-83-9Relevant academic research and scientific papers
Nucleus-independent chemical shift (NICS) as a criterion for the design of new antifungal benzofuranones
González-Chávez, Marco Martín,González-Chávez, Rodolfo,Méndez, Francisco,Martínez, Roberto,Ni?o-Moreno, Perla Del Carmen,Ojeda-Fuentes, Luis Enrique,Richaud, Arlette,Zerme?o-Macías, María de los ángeles
, (2021/08/30)
The assertion made by Wu et al. that aromaticity may have considerable implications for molecular design motivated us to use nucleus-independent chemical shifts (NICS) as an aromaticity criterion to evaluate the antifungal activity of two series of indol-4-ones. A linear regression analysis of NICS and antifungal activity showed that both tested variables were significantly related (p –1 for Candida glabrata, Candida krusei and Candida guilliermondii with compounds 15-32, 15-15 and 15-1. The MIC for filamentous fungi was 1.95 μg·mL–1 for Aspergillus niger for compounds 15-1, 15-33 and 15-34. The results obtained support the use of NICS in the molecular design of compounds with antifungal activity.
DIRECT SYNTHESIS OF FURANS BY 3 + 2 CYCLOADDITIONS BETWEEN RHODIUM(II) ACETATE STABILIZED CARBENOIDS AND ACETYLENES
Davies, Huw M. L.,Romines, Karen R.
, p. 3343 - 3348 (2007/10/02)
When appropriate substituents are used, rhodium(II) acetate catalyzed decomposition of diazocarbonyls in the presence of acetylenes results in the formation of furans, derived from dipolar intermediates.
