116442-14-9

Basic information

• Product Name: 1-METHYL-3-(METHYLTHIO)-1H-INDOLE
• Synonyms: 1-METHYL-3-(METHYLTHIO)-1H-INDOLE
• CAS NO: 116442-14-9
• Molecular Formula: C₁₀H₁₁NS
• Molecular Weight: 177.27
• Mol File: 116442-14-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-METHYL-3-(METHYLTHIO)-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-3-(METHYLTHIO)-1H-INDOLE(116442-14-9)
• EPA Substance Registry System: 1-METHYL-3-(METHYLTHIO)-1H-INDOLE(116442-14-9)

Safety Data

• Hazardous Substances Data: 116442-14-9(Hazardous Substances Data)

Usage

General Description

1-Methyl-3-(methylthio)-1H-indole, also known as MTMI, is a chemical compound with the molecular formula C10H11NS. It is a derivative of indole, a heterocyclic organic compound. MTMI is commonly used in the synthesis of pharmaceuticals and research chemicals. It has a characteristic sulfur-containing methylthio group attached to the indole ring, giving it unique chemical properties. MTMI is known to exhibit biological activity and has been studied for its potential as a therapeutic agent in various medical applications. It is important to handle MTMI with caution and follow proper safety protocols when working with this compound.

Upstream product

• 603-76-9 1-methylindole 
• 4837-30-3 1-(methylthio)morpholine 
• 54087-15-9 3-(dimethylsulfonio)indolide 
• 40167-20-2 N-(methylthio)phthalimide 
• 67-68-5 dimethyl sulfoxide 
• 120-72-9 indole 
• 20277-69-4 sodium methansulfinate 
• 40015-10-9 3-methylthioindole 
• 74-88-4 methyl iodide 

Downstream Products

• 603-76-9 1-methylindole 
• 120517-34-2 1-methyl-2,3-bis(methylthio)indole 

Relevant articles and documents

INDOLE- AND PYRROLE-SULFONIUM YLIDES

Electrophilic substitution of indole and pyrrole with sulfoxides and acid anhydrides leads to the formation of indole-3-sulfonium salts and pyrrole-2-sulfonium salts.These are deprotonated with potassium carbonate to give indole-3-sulfonium ylides and pyr

Switchable regioselection of C-H thiolation of indoles using different TMS counterions

A switchable regioselectivity in C-H thiolation reaction by simply swapping the counteranions of TMS is reported here for the first time. An exclusive C3-H thiolation of indoles with sodium arylsulfinates was achieved in the presence of TMSCl as a promoter. In contrast, with the use of TMSOTf instead of TMSCl under otherwise identical conditions, a regiospecific C2-H thiolation of indoles was realized with the same set of substrates.

DMSO as oxidant and sulfenylating agent for metal-free oxidation and methylthiolation of alcohol-containing indoles

A simple and efficient methylthiolation protocol was successfully established for the synthesis of ketone-substituted indoles bearing 3-methylthioether moiety. The new synthetic approach featured metal-free oxidation and methylthiolation of alcohol-contai