1164460-14-3

Basic information

• Product Name: 5-(3,4-dimethoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
• Synonyms: 5-(3,4-dimethoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
• CAS NO: 1164460-14-3
• Molecular Formula: C19H17NO3S
• Molecular Weight: 339.40818
• Mol File: 1164460-14-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(3,4-dimethoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3,4-dimethoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one(1164460-14-3)
• EPA Substance Registry System: 5-(3,4-dimethoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one(1164460-14-3)

Safety Data

• Hazardous Substances Data: 1164460-14-3(Hazardous Substances Data)

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 68-11-1 mercaptoacetic acid 
• 104-85-8 para-methylbenzonitrile 

Relevant articles and documents

5-benzylidene-2-phenyl thiazolone compound as well as preparation and application thereof

The invention relates to a 5-benzylidene-2-phenyl thiazolone compound as well as preparation and application thereof. In particular, the compound provided by the invention has a structure shown as a general formula (I), wherein the definitions of each group and substituent are described in the description. The invention further discloses a preparation method of the compound and application of thecompound to the prevention and/or treatment of cancer-related diseases. The compound provided by the invention has superior inhibitory activity on protein-arginine methyltransferases 1 (PRMT1), protein-arginine methyltransferases 5 (PRMT5) and histone demethylase LSD1, and can induce tumor cell apoptosis and retard tumor cells at a G1 stage, so that the compound can be used for preparing a seriesof medicaments for treating diseases related to abnormal activities of the PRMT1, the PRMT5 and the histone demethylase LSD1. The general formula (I) is shown in the description.