1164469-60-6

Basic information

• Product Name: (2RS)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalene-1-yloxy)propan-2-ol monohydrochloride
• CAS NO: 1164469-60-6
• Molecular Weight: 428.959
• Mol File: 1164469-60-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2RS)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalene-1-yloxy)propan-2-ol monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2RS)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalene-1-yloxy)propan-2-ol monohydrochloride(1164469-60-6)
• EPA Substance Registry System: (2RS)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalene-1-yloxy)propan-2-ol monohydrochloride(1164469-60-6)

Safety Data

• Hazardous Substances Data: 1164469-60-6(Hazardous Substances Data)

Usage

Uses

Naftopidil Hydrochloride is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive.

Upstream product

• 2461-42-9 3-(1-naphthyloxy)-1,2-epoxypropane 
• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 90-15-3 α-naphthol 

Relevant articles and documents

NAFTOPIDIL MONOHYDROCHLORIDE DIHYDRATE AND USE THEREOF FOR PREPARATION OF NAFTOPIDIL

PROBLEM TO BE SOLVED: To provide an intermediate that is useful for the preparation of naftopidil (Naftopidil, (2RS)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalene-1-yloxy)propan-2-ol), and a method for preparing naftopidil using the same. SOLUTION: By freeing naftopidil monohydrochloride dihydrate, naftopidil can be obtained in high yield and high purity. In particular, a purity of 99.99% can be achieved without repeating purification operation such as recrystallization multiple times. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2021,JPOandINPIT