116447-38-2Relevant academic research and scientific papers
THE SYNTHESIS AND CHARACTERIZATION OF 2,3-METHANOPYROGLUTAMIC ACID
Mapelli, Claudio,Elrod, Luther F.,Holt, Elizabeth M.,Stammer, Charles H.
, p. 4377 - 4382 (2007/10/02)
Details of the synthesis of 2,3-methanopyroglutamic acid (1), its N-methylamide (7) and N-β-naphthylamide (6) are reported.An NMR study of the conformation of 7 is discussed and the stability of the amide 6 to pyroglutamylaminopeptidase is detailed.The crystal structure of an alkene (4) formed during the pyrolysis of an intermediate pyrazoline (2) indicates that the (Z)-configuration is conserved during nitrogen extrusion.
Synthesis of 2,3-Methano-glutamic and -pyroglutamic Acid
Elrod, Luther F.,Holt, Elizabeth M.,Mapelli, Claudio,Stammer, Charles H.
, p. 252 - 253 (2007/10/02)
2,3-Methano-analogues of glutamic and pyroglutamic acid have been synthesized and the β-naphthylamide of the latter is shown to be stable to pyroglutamic amino peptidase; the crystal structure of the methyl pyroglutamate analogue has been determined.
