1164474-29-6Relevant articles and documents
Catalyst-free synthesis of thiazolidines: Via sequential hydrolysis/rearrangement reactions of 5-arylidenethiazolidin-4-ones at room temperature
Zeng, Fanxun,Zhang, Letian,Shao, Xusheng,Li, Zhong,Xu, Xiaoyong
, p. 1932 - 1938 (2018/03/23)
A catalyst-free sequential reaction involving hydrolysis and intramolecular aza-Michael addition was developed for synthesizing functionalized thiazolidines from 5-arylidenethiazolidin-4-ones at room temperature. A series of thiazolidine-5-carboxylic acids were prepared in good to excellent yields (up to 97% yield) and excellent diastereoselectivities (up to >20:1 dr). This methodology was applicable to the construction of derivatives of thiacloprid and flutianil with good yields.