1164482-67-0Relevant articles and documents
Mixed ligand complexes with 4-aminoantipyrine derivatives to combat natural antioxidant system: Synthesis, characterization and biological studies
Joseph,Rani, G. Ayisha Bibin
, p. 790 - 802 (2015)
Novel 4-aminoantipyrine based mixed ligand metal complexes with the Schiff bases of L1 (L1-4-aminoantipyrine with furfuraldehyde and L2/L3/L4/L5 are and L2-2-aminophenol with salicylaldehyde, L3-2-aminophenol with cinnamaldehyde, L4-2-aminobenzothiazole with salicylaldehyde, L5-2-aminobenzothiazole with cinnamaldehyde) were synthesized. The structures of the mixed ligand complexes were established by analytical and spectral techniques. They were screened for in vitro antimicrobial activity against of bacteria and fungi by disc diffusion method. The interaction of metal complexes with calf thymus-DNA (CT-DNA) was investigated by UV-visible, cyclic voltammetry, viscosity and thermal denaturation studies. DNA interaction studies suggest that metal complex binds to calf thymus-DNA through intercalation mode. Superoxide dismutase activity of these complexes has also been studied. The free ligands and their metal complexes have been tested for in vitro antioxidant activity by the reduction of 1,1-diphenyl-2-picryl hydrazyl (DPPH). The antioxidant activities of the complexes were studied and compared with the activity of ascorbic acid. Copper(II) complex showed superior antioxidant activity than other complexes.
Predictions and correlations of structure activity relationship of some aminoantipyrine derivatives on the basis of theoretical and experimental ground
Ali, Parvez,Meshram, Jyotsna,Sheikh, Javed,Tiwari, Vandana,Dongre, Rajendra,Hadda, Taibi B.
, p. 157 - 164 (2012)
A series of 4-aminoantipyrine derivatives were produced by condensing aromatic primary amine, namely, 4-aminoantipyrine with different aryl carbonyls which occurred cleanly and efficiently without using any catalyst at room temperature. Their structures w
Synthesis, spectral characterization, docking analysis, DNA binding/cleavage, antimicrobial and cytotoxic activity of new dimeric antipyrine-Schiff base metal complexes
Alaghaz, Abdel-Nasser M.A.,Alturiqi, Amani S.,Ammar, Reda A.,Zayed, Mohamed E.
, p. 199 - 212 (2019)
In the present study, a new series of novel Schiff base ligand derived from (furan-2-carbaldehyde and 4-aminoantipyrine) and dimeric metal(II) complexes with the composition of [MLCl2]2, where M=Cu(II), Co(II), Ni(II) and Zn(II) have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductivity measurements, FT-IR, UV-visible, 1H NMR, 13C NMR, EPR, MS (ESI), XRD, SEM and EDX studies. The spectral data recommend that the dimeric metal complexes embrace octahedral geometry around the central metal ions. The DMF solutions of the dimeric metal complexes demonstrate the lower molar conductance values which might be due to the non-electrolytic nature of the complexes (5.67-13.24 ?-1 mol-1 cm-2). The biological studies involved are DNA interaction (binding and damage) antimicrobial, anti-proliferative and molecular docking. DNA interaction of these complexes carried out with using calf thymus DNA (CT-DNA) by electronic absorption titration, viscometric measurement which revealed that the synthesized dimeric complexes interact with DNA through intercalative binding mode. A gel electro-phoresis assay testifies the ability of complexes to cleave supercoiled pUC19 DNA in the presence of hydrogen peroxide as an activator. The synthesized compounds were initiated from their biological perspective. The antimicrobial assay indicates that dimeric complexes are good antimicrobial agents. Besides, in vitro antiproliferative activity of dimeric complexes were investigated on MCF-7, Hep G2, HBL-100 cell lines using an MTT assay. In addition, the molecular docking study was accomplished to considerate the nature of binding of the synthesized compounds with protein and DNA.
Synthesis, spectral-characterization, biological and DFT studies of mixed ligand metal(II) complexes of 1,10-phenanthroline bearing 2-aminothiazole moiety
Dhanaraj, Chellaian Justin,Remya, Dharmasingh Sobhanabai
, p. 536 - 544 (2020)
The Schiff base ligand L is developed from furan-2-carboxaldehyde, 4-aminoantipyrine together with 2-aminothiazole. The mixed ligand complexes are developed from the condensation of above Schiff base ligand L, 1,10-phenanthroline as well as metal(II) acet
Organic synthesis of Schiff base compound and method for preparing crystal by the same
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Paragraph 0033; 0039; 0065-0071, (2018/09/11)
The invention relates to an organic synthesis method of Schiff base compounds and a method for preparing crystals by the same. The organic synthesis method of the Schiff base compounds includes the steps of dissolving active ketone or active aldehyde and
