116475-72-0

Upstream product

• 7051-16-3 1-chloro-3,5-dimethoxybenzene 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 139027-45-5 5-Chloro-7-methoxy-4-oxo-2-phenyl-4H-1-benzopyran 
• 116475-73-1 5-chloro-7-methoxy-4-oxo-3-phenyl-4H-1-benzopyran 
• 112954-09-3 5-chloro-7-hydroxy-2-methyl-3-phenyl-4-oxo-4H-1-benzopyran 
• 112953-66-9 (5-Chloro-2-methyl-4-oxo-3-phenyl-4H-chromen-7-yloxy)-acetic acid 
• 112953-74-9 (5-Chloro-4-oxo-3-phenyl-4H-chromen-7-yloxy)-acetic acid ethyl ester 
• 112953-93-2 5-chloro-7-hydroxy-4-oxo-3-phenyl-4H-1-benzopyran 
• 112953-44-3 ((5-chloro-4-oxo-3-phenyl-4H-1-benzopyran-7-yl)oxy)acetic acid 

Relevant academic research and scientific papers

Aryloxyacetic acid diuretics with uricosuric activity. II. Substituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids and the related compounds

Di- and tri-substituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids, and 4-oxo-3-phenyl-4H-furo[2,3-h][1]benzopyran-8-carboxylic acid were synthesized and tested for natriuretic and uricosuric activities. Among the compounds tested, 3,5-disubstituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids (6c-f, h, n and x) showed potent natriuretic and uricosuric activities, whereas 4-oxo-3-phenyl-4H-furo[2,3-h][1]benzopyran-8-carboxylic acid (6dd) possessed only potent natriuretic activity. The structure-activity relationships are also discussed.

Aryloxy acetic acid diuretics with uricosuric activity. I. Polycyclic aryloxy acetic acids

In order to obtain lead compounds for uricosuric diuretics, various polycyclic aryloxy acetic acids [isoindole derivative (7), quinazoline derivative (15), benzopyran derivative (20), xanthone derivative (24), benzofuran derivative (30) and indene derivat