116475-74-2

Upstream product

• 112953-93-2 5-chloro-7-hydroxy-4-oxo-3-phenyl-4H-1-benzopyran 
• 106-95-6 allyl bromide 

Downstream Products

• 139027-56-8 7-Hydroxy-4-oxo-3-phenyl-8-propyl-4H-1-benzopyran 
• 139048-24-1 2,3-Dihydro-7-hydroxy-4-oxo-3-phenyl-8-propyl-4H-1-benzopyran 
• 139027-55-7 5-Chloro-8,9-dihydro-8-hydroxymethyl-4-oxo-3-phenyl-4H-furo<2,3-h><1>benzopyran 
• 116475-65-1 5-Chloro-8,9-dihydro-4-oxo-3-phenyl-4H-furo<2,3-h><1>benzopyran-8-carboxylic acid 
• 116475-75-3 8-Allyl-5-chloro-7-hydroxy-4-oxo-3-phenyl-4H-1-benzopyran 

Relevant academic research and scientific papers

Aryloxyacetic acid diuretics with uricosuric activity. II. Substituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids and the related compounds

Di- and tri-substituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids, and 4-oxo-3-phenyl-4H-furo[2,3-h][1]benzopyran-8-carboxylic acid were synthesized and tested for natriuretic and uricosuric activities. Among the compounds tested, 3,5-disubstituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids (6c-f, h, n and x) showed potent natriuretic and uricosuric activities, whereas 4-oxo-3-phenyl-4H-furo[2,3-h][1]benzopyran-8-carboxylic acid (6dd) possessed only potent natriuretic activity. The structure-activity relationships are also discussed.