116480-86-5Relevant academic research and scientific papers
Peptide-Chain Elongation Using Unprotected Amino Acids in a Micro-Flow Reactor
Fuse, Shinichiro,Masuda, Koshiro,Otake, Yuma,Nakamura, Hiroyuki
, p. 15091 - 15097 (2019)
Conventional peptide synthesis requires a deprotection step after each amidation step, which decreases synthetic efficiency. Therefore, peptide synthesis using unprotected amino acids is considered an ideal approach. Here, we report peptide chain elongati
Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders
De Nanteuil, Guillaume,Gloanec, Philippe,Béguin, Suzette,Giesen, Peter L. A.,Hemker, H. Coenraad,Mennecier, Philippe,Rupin, Alain,Verbeuren, Tony J.
, p. 5047 - 5050 (2007/10/03)
The synthesis and evaluation of inhibitors of activated protein C (aPC) are reported. This serine protease is partly responsible for the degradation of factor Villa, involved in the regulation of bleeding in hemophilia A. Benzamidine-containing derivatives were found to be potent aPC inhibitors, some of them showing selectivity against the procoagulant protease thrombin. Moreover, compound 1 significantly restored the generation of thrombin in hemophiliac plasma.
