116485-96-2 Usage
Description
2H-chroMen-2-ol, also known as 2H-chromen-2-ol, is a chemical compound with the molecular formula C9H6O2. It is a derivative of coumarin and belongs to the class of compounds known as chromenols. 2H-chroMen-2-ol exhibits potential pharmacological properties, such as anticoagulant and neuroprotective effects, along with antioxidant and anti-inflammatory activities. Its promising results in experimental studies suggest potential therapeutic applications in various diseases, including cardiovascular and neurodegenerative disorders. Further research and clinical studies are required to fully elucidate the benefits and mechanisms of action of 2H-chroMen-2-ol.
Uses
Used in Pharmaceutical Industry:
2H-chroMen-2-ol is used as a potential therapeutic agent for its anticoagulant properties, which can help in the prevention and treatment of blood clot-related disorders. Its neuroprotective effects also make it a candidate for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's.
Used in Cardiovascular Applications:
In the cardiovascular field, 2H-chroMen-2-ol is utilized for its potential to protect the heart and blood vessels from oxidative stress and inflammation, which are key factors in the development of cardiovascular diseases.
Used in Neurodegenerative Applications:
2H-chroMen-2-ol is employed as a neuroprotective agent to combat the oxidative stress and inflammation associated with neurodegenerative disorders, potentially slowing down or halting the progression of these diseases.
Used in Antioxidant and Anti-inflammatory Applications:
Due to its antioxidant and anti-inflammatory activities, 2H-chroMen-2-ol can be used in various applications where these properties are beneficial, such as in the development of drugs for inflammatory and oxidative stress-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 116485-96-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,4,8 and 5 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 116485-96:
(8*1)+(7*1)+(6*6)+(5*4)+(4*8)+(3*5)+(2*9)+(1*6)=142
142 % 10 = 2
So 116485-96-2 is a valid CAS Registry Number.
116485-96-2Relevant articles and documents
Catalytic Asymmetric Cross-Dehydrogenative Coupling of 2H-Chromenes and Aldehydes
Pan, Xinhui,Liu, Xigong,Sun, Shutao,Meng, Zhilin,Liu, Lei
, p. 1187 - 1190 (2018)
The first catalytic asymmetric cross-dehydrogenative coupling of 2H-chromenes with aldehydes using o-chloranil (3,4,5,6-tetrachloro-1,2- benzoquinone) as an oxidant has been described. The organocatalytic process is tolerated with a broad range of structurally and electronically varied 2H-chromenes and aldehydes with good yield and high enantiocontrol.
Formal Carbene Insertion into C?O or C?N Bond: An Efficient Strategy for the Synthesis of 2-Substituted 2H-Chromene Derivatives from Chromene Acetals or Hemiaminal Ethers
Zhang, Dan,Hu, Wenhao
supporting information, p. 2446 - 2452 (2018/05/14)
We report the palladium/Br?nsted acid co-catalyzed formal insertion of carbene into the C?O or C?N bond of 2H-chromene acetals or hemiaminal ethers. This transformation was initiated by the Br?nsted acid-promoted cleavage of the C?O or C?N bond, followed by modification of the leaving alcohol or amino fragments with palladium carbenes, and reassembly of the modified fragments. A variety of C-2 functionalized 2H-chromene derivatives were obtained in moderate yield (43~75%) with good to excellent diastereoselectivities (up to >95:5 dr) under mild conditions. (Figure presented.).
Trimethylsilyl iodide mediated one-pot synthesis of 2-allyl-2H-chromenes
Padhi, Birakishore,Reddy, D. Srinivas,Mohapatra, Debendra K.
, p. 542 - 547 (2015/01/30)
A new and efficient metal-free trimethylsilyl iodide (TMSI) catalyzed one-pot synthesis of 2-allyl-2H-chromenes has been developed that takes place under mild conditions. The synthesis proceeds through a Wittig reaction by using (triphenylphosphoranylidene)acetaldehyde to form an ohydroxycinnamaldehyde derivative followed by a tandem isomerization and C-O and C-C bond-forming reactions. The procedure was carried out at room temperature in the presence of 20 mol-% of TMSI and allyltrimethylsilane in tetrahydrofuran (THF) and provided the 2-allyl-2H-chromenes in good to excellent yields.