1165-38-4

Usage

Uses

Used in Medicinal Chemistry:
2,3-Seco-5-androstan-17-one-2,3-dicarboxylic acid is used as a chemical compound in medicinal chemistry for its potential to develop new pharmaceuticals targeting hormonal disorders and related conditions. Its unique structure and functional groups offer opportunities for the creation of novel therapeutic agents.
Used in Drug Discovery:
In the field of drug discovery, 2,3-Seco-5-androstan-17-one-2,3-dicarboxylic acid is utilized as a lead compound for the development of innovative drugs. Its unprecedented molecular architecture and synthetic challenges make it an interesting subject for researchers aiming to explore new avenues in medical treatment.
Used in Organic Synthesis:
2,3-Seco-5-androstan-17-one-2,3-dicarboxylic acid is used as a complex molecular structure in organic synthesis, providing a platform for the synthesis of new compounds with potential applications in various fields, including pharmaceuticals and chemical biology.
Used in Chemical Biology:
In chemical biology, 2,3-Seco-5-androstan-17-one-2,3-dicarboxylic acid is employed as a unique molecular scaffold for the study of biological processes and the development of bioactive molecules. Its complex structure allows for the exploration of new interactions and mechanisms within biological systems.
Overall, the diverse applications of 2,3-Seco-5-androstan-17-one-2,3-dicarboxylic acid across different industries highlight its potential as a versatile compound with significant implications for future research and development in medicine and related fields.

InChI:InChI=1/C19H28O5/c1-18-8-7-14-12(13(18)5-6-15(18)20)4-3-11(9-16(21)22)19(14,2)10-17(23)24/h11-14H,3-10H2,1-2H3,(H,21,22)(H,23,24)

Upstream product

• 17006-89-2 17β-Hydroxy-3-acetyl-5α-androsten-(2) 
• 10148-98-8 (3S,5S,8R,9S,10S,13S,14S,17S)-3-ethynyl-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol 
• 481-29-8 Epiandrosterone 
• 17006-92-7 17-Oxo-3-acetyl-5α-androsten-(2) 
• 54632-47-2 ((3S,5S,8R,9S,10S,13S,14S,17S)-3,17-Diacetoxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl)-oxo-acetic acid methyl ester 

Relevant academic research and scientific papers

Steroidal nitrone inhibitors of 5α-reductase

This paper describes the rational design and synthesis of novel inhibitors of human steroid 5α-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5α-reductase isozymes. Judicious placement of the nitrone into the steroid A-ring provided an effective and stable transition-state mimic of the postulated enolate intermediate involved in the conversion of testosterone into dihydrotestosterone.

CYP11B, CYP17, AND/OR CYP21 INHIBITORS

Provided herein are inhibitors of CYP11B, CYP17, and/or CYP21 enzymes of Formula (Z), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), or (XVII). Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions. Formula (Z)

NOVEL CYP17 INHIBITORS

Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.