116510-01-1Relevant articles and documents
A short three-component synthesis of tricyclic compounds
Hilt, Gerhard,Korn, Tobias J.,Smolko, Konstantin I.
, p. 241 - 243 (2003)
A facile reaction sequence, consisting of a palladium-catalyzed Sonogashira coupling, a cobalt-catalyzed Diels - Alder reaction and a subsequent cyclization initiated by a bromine-lithium exchange reaction, allows a three-component synthesis of tricyclic
COMPOUNDS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS
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Page/Page column 127; 128, (2019/07/20)
Provided are compounds having Formula (1), compositions thereof, and methods of modulating CFTR activity. Also provided are methods of treating a condition associated with decreased CFTR activity comprising administering to a subject an effective amount o
A 1,5-enynes alcohol compound and its synthetic method and application
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Paragraph 0031-0034, (2016/11/28)
The invention discloses a 1,5-enynic alcohol compound as well as a synthesis method and application thereof. The 1, 5-enynic alcohol compound has the structural formula as shown in the description, wherein R1 represents alkyl or aryl, R represents halogen, alkyl, alkoxy, nitro or an ester group, and w is an arbitrary integer from 0 to 2. The 1,5-enynic alcohol compound can be introduced into a terminal group of saccharide by a Fishcher glycosidation method and a Schmidt glycosidation method to be an ether leaving group of a glycosyl donor, wherein the leaving group can perform ring closing and leaving under the activation of a catalytic amount Au (I), so that a coupling reaction is performed on the glycosyl donor and a glycosyl receptor so as to build a glycosidic bond; the 1,5-enynic alcohol compound can be directly introduced into a terminal position of the saccharide as a saccharide terminal position protecting group; the protecting group has certain tolerance to an acid condition and al alkali condition, has certain high temperature resistance, has good stability in the synthesis operation process of protection and deprotection of a saccharide module, and can simplify synthesis steps of the saccharide module.
Gold-catalyzed stereoselective synthesis of Di- or trisubstituted olefins possessing a 1,4-diene framework via intramolecular allylation of alkynes
Horino, Yoshikazu,Nakashima, Yuichi,Hashimoto, Ken,Kuroda, Shigeyasu
supporting information; experimental part, p. 2879 - 2882 (2011/03/18)
The cationic gold(I)-catalyzed reaction of 1-alkynyl-2-allylsilylbenzenes with water results in intramolecular allylation of the alkynes via 7-exo-dig cyclization to give 1,4-dienes in good yield with excellent stereoselectivities. Georg Thieme Verlag Stu
THE SYNTHESIS OF 11-13 MEMBERED DIACETYLENIC AND 18-MEMBERED TETRAACETYLENIC RING SYSTEMS
Just, George,Singh, Rina
, p. 5981 - 5984 (2007/10/02)
The sysnthesis of title compounds is described, starting from o-dibromobenzene.The palladium catalysed coupling of the latter with acetylenes occurred in a step-wise fashion, when no cocatalyst (CuI) was used.