116511-50-3

Upstream product

• 116511-49-0 Benzoic acid (3R,4R,5S)-5-((1E,3E)-4-methoxycarbonyl-buta-1,3-dienyl)-4-(toluene-4-sulfonyloxy)-tetrahydro-furan-3-yl ester 
• 88751-27-3 ethylene acetal of 2,5-anhydro-4-O-benzoyl-3-O-p-toluenesulfonyl-D-xylose 
• 116511-48-9 Benzoic acid (3R,4S,5R)-5-dihydroxymethyl-4-(toluene-4-sulfonyloxy)-tetrahydro-furan-3-yl ester 
• 2181-98-8 <3-carbomethoxy-propen-(2)-yl-(1)>-triphenylphosphoniumbromide 

Downstream Products

• 116511-51-4 Benzoic acid (2S,3R,4R)-4-hydroxy-2-(4-methoxycarbonyl-butyl)-tetrahydro-furan-3-yl ester 
• 116511-57-0 Benzoic acid (3R,4S,5S)-4-hydroxy-5-(4-methoxycarbonyl-butyl)-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

Stereospecific synthesis of (+)-oxybiotin from D-xylose

A new 14-step synthesis of (+)-oxybiotin, an oxygen analogue of (+)-biotin, was achieved starting from D-xylose by use of selected 2,5-anhydro sugar derivatives as key intermediates.

STEREOSPECIFIC SYNTHESIS OF (+)-OXYBIOTIN FROM D-XYLOSE. PREPARATION OF THE FINAL CHIRAL (+)-OXYBIOTIN PRECURSOR

A stereospecific synthesis of 2(S)-carbomethoxy-butyl-3(R),4(S)-diacetamido-tetrahydrofurane (11), the final chiral precursor in a new synthesis of (+)-oxybiotin has been achieved from 2,5-anhydro-D-xylose derivative 1.