116529-65-8 Usage
Description
2-BROMO-6-CHLOROBENZOYL CHLORIDE is a chemical compound that belongs to the class of benzoyl chlorides. It is a reactive and versatile compound with strong acylating properties, commonly used in organic synthesis for the preparation of pharmaceuticals, agrochemicals, and dyes. Its unique structure allows for the modification of natural products and the development of new materials.
Uses
Used in Pharmaceutical Industry:
2-BROMO-6-CHLOROBENZOYL CHLORIDE is used as a key intermediate for the synthesis of various pharmaceuticals. Its strong acylating ability allows for the formation of amide and ester linkages, which are essential in the development of new drug molecules.
Used in Agrochemical Industry:
2-BROMO-6-CHLOROBENZOYL CHLORIDE is used as a building block in the synthesis of agrochemicals, such as insecticides and herbicides. Its reactivity enables the formation of various functional groups, contributing to the development of effective and targeted agrochemicals.
Used in Dye Industry:
2-BROMO-6-CHLOROBENZOYL CHLORIDE is used as a precursor in the synthesis of dyes, particularly those with specific color properties. Its versatile chemical structure allows for the creation of dyes with unique characteristics, suitable for various applications.
Used in Heterocyclic Compound Synthesis:
2-BROMO-6-CHLOROBENZOYL CHLORIDE is used as a reagent in the synthesis of various heterocyclic compounds. Its strong acylating properties facilitate the formation of heterocyclic rings, which are important in the development of new materials and pharmaceuticals.
Used in Natural Product Modification:
2-BROMO-6-CHLOROBENZOYL CHLORIDE is used as a modifying agent for the functionalization of natural products. Its reactivity allows for the introduction of new functional groups, enhancing the properties and applications of these natural compounds.
Used in New Material Development:
2-BROMO-6-CHLOROBENZOYL CHLORIDE is used as a component in the development of new materials, such as polymers and coatings. Its unique chemical structure contributes to the creation of materials with specific properties, suitable for various industrial applications.
Safety Precautions:
Due to the reactive nature of 2-BROMO-6-CHLOROBENZOYL CHLORIDE, it should be handled with care and used in a well-ventilated area with appropriate safety measures, such as wearing protective clothing and using proper containment systems.
Check Digit Verification of cas no
The CAS Registry Mumber 116529-65-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,5,2 and 9 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 116529-65:
(8*1)+(7*1)+(6*6)+(5*5)+(4*2)+(3*9)+(2*6)+(1*5)=128
128 % 10 = 8
So 116529-65-8 is a valid CAS Registry Number.
116529-65-8Relevant articles and documents
Utilization of BozPhos as an Effective Ligand in Enantioselective C-H Functionalization of Cyclopropanes: Synthesis of Dihydroisoquinolones and Dihydroquinolones
Mayer, Camilla,Ladd, Carolyn L.,Charette, André B.
supporting information, p. 2639 - 2644 (2019/04/17)
The bisphosphine monoxide (R,R)-BozPhos enables enantioselective C-H functionalization of cyclopropanes in a palladium-catalyzed cyclization. The synthesis of a broad spectrum of dihydroisoquinolones and dihydroquinolones in good yields and high enantiomeric excess was achieved through the use of this hemilabile ligand. Furthermore, the isolation of an intermediary palladium(II)-BozPhos complex after oxidative addition was successful and a second complex provided further insight into bond length and angles through a crystal structure.
Carbanionic friedel-crafts equivalents. Regioselective directed Ortho and remote metalation-C-N cross coupling routes to acridones and dibenzo[b,f]azepinones
MacNeil, Stephen L.,Gray, Matthew,Gusev, Dmitry G.,Briggs, Laura E.,Snieckus, Victor
supporting information; experimental part, p. 9710 - 9719 (2009/04/07)
(Chemical Equation Presented) Carbanion-mediated general regioselective routes to acridones 4 (Table 2) and dibenzo[b,f]azepinones 20 (Table 4) are described. Buchwald-Hartwig C-N cross coupling of o-halo benzamides 1 with anilines 2 or 16, followed by simple N-methylation, dependably provides N-methyl diarylamines 3 (Table 1) and 18 (Table 3). Upon treatment with LDA, 3 and 18 are converted into acridones 4 and dibenzo[b,f]azepinones 20, respectively, in good to excellent yields with regioselectivity which depends upon the presence or absence of directed metalation groups (DMGs). Brief investigations as follows are described: the synthesis of desmethyl acridone 15 (Scheme 4), an attempt to effect a double-directed remote metalation sequence which leads only to a monocyclization product 13 (Scheme 3), and an analogous but nonregioselective route to a xanthone 22 and dibenzo[b,f]oxepinone 24 (Scheme 5). DFT calculations reveal low energy conformations for compounds 18b and 23 which account for product formation and indicate that the cyclization reactions are under kinetic control.
