116539-01-6

Basic information

• Product Name: 3-Thiophenecarboxylicacid,5-amino-
• Synonyms: 3-Thiophenecarboxylicacid,5-amino-;3-Thiophenecarboxylicacid,5-amino-(9CI);5-aminothiophene-3-carboxylic acid
• CAS NO: 116539-01-6
• Molecular Formula: C5H5NO2S
• Molecular Weight: 143.1637
• Product Categories: CARBOXYLICACID;AMINOACID
• Mol File: 116539-01-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Thiophenecarboxylicacid,5-amino-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Thiophenecarboxylicacid,5-amino-(116539-01-6)
• EPA Substance Registry System: 3-Thiophenecarboxylicacid,5-amino-(116539-01-6)

Safety Data

• Hazardous Substances Data: 116539-01-6(Hazardous Substances Data)

Upstream product

• 40357-96-8 5-nitro-thiophene-3-carboxylic acid 

Relevant articles and documents

New geldanamycin derivatives with anti Hsp properties by mutasynthesis

Mutasynthetic supplementation of the AHBA blocked mutant strain of S. hygroscopicus, the geldanamycin producer, with 21 aromatic and heteroaromatic amino acids provided new nonquinoid geldanamycin derivatives. Large scale (5 L) fermentation provided four new derivatives in sufficient quantity for full structural characterisation. Among these, the first thiophene derivative of reblastatin showed strong antiproliferative activity towards several human cancer cell lines. Additionally, inhibitory effects on human heat shock protein Hsp90α and bacterial heat shock protein from H. pylori HpHtpG were observed, revealing strong displacement properties for labelled ATP and demonstrating that the ATP-binding site of Hsps is the target site for the new geldanamycin derivatives.